Bañares A, Hernández-García C, Fernández-Gutiérrez B, Jover J A
Service of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain.
Rheum Dis Clin North Am. 1998 Nov;24(4):771-84, ix. doi: 10.1016/s0889-857x(05)70041-7.
Eye inflammation, especially uveitis, is a prominent feature of spondyloarthropathies. Uveitis associated with ankylosing spondylitis and Reiter's syndrome usually is a unilateral acute anterior uveitis with a high tendency to recur sometimes in the contralateral eye. Uveitis associated with undifferentiated spondyloarthropathy, inflammatory bowel disease, and psoriasis may be less characteristic in its presentation, with a higher tendency to posterior pole involvement, bilaterality, and chronicity. Although acute anterior uveitis is grouped into the spectrum of human leukocyte antigen B27-related disease, other genetic and environmental factors including infections by gram-negative bacteria and gut inflammation can play a role in its pathogenesis. The prognosis of uveitis usually is excellent with topical treatment, and only those with posterior pole involvement or a high tendency to recur or to chronicity might benefit from immunosuppressive therapy.
眼部炎症，尤其是葡萄膜炎，是脊柱关节病的一个突出特征。与强直性脊柱炎和赖特综合征相关的葡萄膜炎通常为单侧急性前葡萄膜炎，有时对侧眼复发倾向较高。与未分化脊柱关节病、炎症性肠病和银屑病相关的葡萄膜炎在表现上可能不那么典型，后极部受累、双侧性和慢性化的倾向更高。虽然急性前葡萄膜炎被归为人类白细胞抗原B27相关疾病谱，但其他遗传和环境因素，包括革兰氏阴性菌感染和肠道炎症，也可能在其发病机制中起作用。葡萄膜炎经局部治疗后预后通常良好，只有那些后极部受累、复发倾向高或有慢性化倾向的患者可能从免疫抑制治疗中获益。
