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1
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Infect Dis Obstet Gynecol. 1998;6(5):197-203. doi: 10.1002/(SICI)1098-0997(1998)6:5<197::AID-IDOG2>3.0.CO;2-1.
2
Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.用于降低艾滋病毒感染母婴传播风险的抗逆转录病毒药物。
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Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study.儿科艾滋病临床试验组076研究中使用的母婴齐多夫定治疗方案的安全性。
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4
Is intrapartum intravenous zidovudine for prevention of mother-to-child HIV-1 transmission still useful in the combination antiretroviral therapy era?在联合抗逆转录病毒治疗时代，产时静脉注射齐多夫定预防母婴 HIV-1 传播是否仍然有用？
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5
Oral zidovudine during labor to prevent perinatal HIV transmission, Bangkok: tolerance and zidovudine concentration in cord blood. Bangkok Collaborative Perinatal HIV Transmission Study Group.分娩期间口服齐多夫定预防围产期艾滋病毒传播，曼谷：耐受性及脐带血中齐多夫定浓度。曼谷围产期艾滋病毒传播协作研究小组
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ACTG 076 and reduction of perinatal transmission.艾滋病临床试验组076号研究与围产期传播的减少
Update Natl Minor AIDS Counc. 1997 Mar:4-7, 9.
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Effect of zidovudine treatment in late pregnancy on HIV-1 in utero transmission.妊娠晚期齐多夫定治疗对HIV-1宫内传播的影响。
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Pediatrics. 2002 Sep;110(3):e35. doi: 10.1542/peds.110.3.e35.

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A stability-indicating LC-MS/MS method for zidovudine: Identification, characterization and toxicity prediction of two major acid degradation products.一种用于齐多夫定的稳定性指示液相色谱-串联质谱法：两种主要酸降解产物的鉴定、表征及毒性预测
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本文引用的文献

1
Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study.儿科艾滋病临床试验组076研究中使用的母婴齐多夫定治疗方案的安全性。
AIDS. 1998 Oct 1;12(14):1805-13. doi: 10.1097/00002030-199814000-00012.
2
Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society-USA Panel.1998年艾滋病病毒感染的抗逆转录病毒治疗：美国国际艾滋病学会专家组的更新建议。
JAMA. 1998 Jul 1;280(1):78-86. doi: 10.1001/jama.280.1.78.
3
Maternal viral genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent perinatal transmission of human immunodeficiency virus type 1 in pediatric AIDS Clinical Trials Group Protocol 076.在儿童艾滋病临床试验组方案076中，母亲的病毒基因型齐多夫定耐药性以及齐多夫定治疗在预防围产期人类免疫缺陷病毒1型传播方面的罕见失败情况。
J Infect Dis. 1998 Mar;177(3):557-64. doi: 10.1086/514228.
4
A transplacental carcinogenicity bioassay in CD-1 mice with zidovudine.用齐多夫定在CD-1小鼠中进行的经胎盘致癌性生物测定。
Fundam Appl Toxicol. 1997 Aug;38(2):195-8. doi: 10.1006/faat.1997.2342.
5
Clinical pharmacokinetics of zidovudine. An update.齐多夫定的临床药代动力学。最新进展。
Clin Pharmacokinet. 1996 Apr;30(4):251-62. doi: 10.2165/00003088-199630040-00001.
6
Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.母亲的病毒载量、齐多夫定治疗与人类免疫缺陷病毒1型母婴传播风险。儿童艾滋病临床试验组方案076研究小组。
N Engl J Med. 1996 Nov 28;335(22):1621-9. doi: 10.1056/NEJM199611283352201.
7
Disposition of zidovudine in obese pregnant women with human immunodeficiency virus type 1 infection.齐多夫定在感染1型人类免疫缺陷病毒的肥胖孕妇中的处置情况。
J Infect Dis. 1996 Sep;174(3):673. doi: 10.1093/infdis/174.3.673.
8
Economic impact of treatment of HIV-positive pregnant women and their newborns with zidovudine. Implications for HIV screening.齐多夫定治疗HIV阳性孕妇及其新生儿的经济影响。对HIV筛查的启示。
JAMA. 1996 Jul 10;276(2):132-8.
9
Perinatal HIV infection and the effect of zidovudine therapy on transmission in rural and urban counties.围产期HIV感染以及齐多夫定治疗对农村和城市县份传播的影响。
JAMA. 1996 May 15;275(19):1483-8.
10
The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: phase I acquired immunodeficiency syndrome clinical trials group study (protocol 082). Zidovudine Collaborative Working Group.齐多夫定在妊娠晚期感染人类免疫缺陷病毒的孕妇及其婴儿中的药代动力学和安全性：I期获得性免疫缺陷综合征临床试验组研究（方案082）。齐多夫定协作工作组
Am J Obstet Gynecol. 1993 May;168(5):1510-6. doi: 10.1016/s0002-9378(11)90791-1.

齐多夫定

Zidovudine.

作者信息

Sperling R

机构信息

Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai Medical Center, New York, NY 10029-6574, USA.

出版信息

Infect Dis Obstet Gynecol. 1998;6(5):197-203. doi: 10.1002/(SICI)1098-0997(1998)6:5<197::AID-IDOG2>3.0.CO;2-1.

DOI:10.1002/(SICI)1098-0997(1998)6:5<197::AID-IDOG2>3.0.CO;2-1
PMID:9894173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1784811/
Abstract

Zidovudine was the first agent approved for treatment of HIV disease, and since its widespread availability in 1987, the pharmacokinetic disposition and clinical effects of ZDV have been extensively evaluated. In addition to its utility as a component of a multidrug combination regimen for the treatment of adult and pediatric HIV-1 infection, it is the only agent approved by the FDA for the prevention of mother-to-child HIV-1 transmission. The effectiveness of ZDV for the prevention of mother-to-child HIV-1 transmission has been demonstrated in several studies. The optimal time during gestation to initiate ZDV therapy and the relative importance of the intrapartum and newborn components is the focus of both current interventional and observational studies. Until more information is available from these trials, the combined maternal/newborn ZDV regimen studied in ACTG 076 remains the recommended treatment regimen of choice in the United States.

摘要

齐多夫定是首个被批准用于治疗HIV疾病的药物，自1987年广泛供应以来，齐多夫定的药代动力学特性和临床效果已得到广泛评估。除了作为治疗成人和儿童HIV-1感染的多药联合治疗方案的组成部分外，它是美国食品药品监督管理局（FDA）批准的唯一用于预防母婴HIV-1传播的药物。多项研究已证明齐多夫定预防母婴HIV-1传播的有效性。孕期开始齐多夫定治疗的最佳时间以及分娩期和新生儿期用药的相对重要性是当前干预性研究和观察性研究的重点。在从这些试验获得更多信息之前，在艾滋病临床试验组（ACTG）076研究中使用的孕产妇/新生儿联合齐多夫定治疗方案仍是美国推荐的首选治疗方案。