Sarica K, Türkölmez K, Koşar A, Alçiğir G, Ozdiler E, Göğüş O
Department of Urology, Ibn-i Sina Hospital, Medical School, Ankara, Turkey.
J Endourol. 1998 Dec;12(6):505-8. doi: 10.1089/end.1998.12.505.
To evaluate the immune pathologic effects of high-energy shockwave (HESW) application on glomerular and tubular basal membrane antibody (IgG) formation, an experimental study on rats has been performed. Following application of different numbers of shockwaves (100-200-500), the presence of antibody was examined with the direct immunofluorescent technique 2 weeks and 3 months postprocedure. Whereas specimens examined after 2 weeks showed antibody formation in only one animal (500 HESWs), being located in the tubular tissues, all treated kidneys demonstrated various degrees of antibody formation in both tubular and glomerular tissues after 3 months. Antibody formation had a close relation to the number of HESWs applied and the time of examination after shockwave application. Apart from the well-defined functional and morphologic side effects of shockwave therapy, the possibility of immunologic alterations after this form of therapy has to be evaluated thoroughly in both clinical and experimental studies.
为评估高能冲击波（HESW）作用对肾小球和肾小管基底膜抗体（IgG）形成的免疫病理效应，已对大鼠进行了一项实验研究。在施加不同数量的冲击波（100 - 200 - 500）后，于术后2周和3个月采用直接免疫荧光技术检测抗体的存在情况。术后2周检查的标本中，仅一只动物（接受500次HESW）在肾小管组织中出现抗体形成，而所有接受治疗的肾脏在3个月后均在肾小管和肾小球组织中表现出不同程度的抗体形成。抗体形成与施加的HESW数量以及冲击波施加后的检查时间密切相关。除了冲击波疗法明确的功能和形态学副作用外，这种治疗方式后免疫改变的可能性必须在临床和实验研究中进行全面评估。
