Fox J, George A J, Newton J R, Parsons A D, Stuart G K, Stuart J, Sturdee D W
Midlands Menopause Study Group: Birmingham Maternity Hospital, UK.
Maturitas. 1993 Dec;18(1):55-64. doi: 10.1016/0378-5122(93)90029-h.
To determine the effect of transdermal oestrogen replacement therapy on the haemostatic balance of menopausal women.
Open, parallel group, prospective study.
Three hospital-based menopause clinics.
Fifty-two postmenopausal women receiving transdermal hormone replacement therapy (Estrapak 50) for 6 months. Comparison group of 48 untreated postmenopausal women studied in parallel.
Changes in platelet number, plasma concentrations of coagulation factors and their natural inhibitors, fibrinolytic activity, and rheological parameters.
Estrapak 50 had no significant thrombophilic effect on any of the outcome measures.
The haemostatic balance and thus the risk of thrombosis would not appear to be upset by this dose of transdermal oestrogen.
确定经皮雌激素替代疗法对绝经后女性止血平衡的影响。
开放性、平行组、前瞻性研究。
三家医院的绝经门诊。
52名接受经皮激素替代疗法（Estrapak 50）6个月的绝经后女性。平行研究48名未经治疗的绝经后女性作为对照组。
血小板数量、凝血因子及其天然抑制剂的血浆浓度、纤溶活性和流变学参数的变化。
Estrapak 50对任何观察指标均无显著的促血栓形成作用。
该剂量的经皮雌激素似乎不会破坏止血平衡，因此也不会增加血栓形成风险。
