葡萄糖-6-磷酸脱氢酶缺乏症中的药物性溶血
Drug-induced haemolysis in glucose-6-phosphate dehydrogenase deficiency.
作者信息
Chan T K, Todd D, Tso S C
出版信息
Br Med J. 1976 Nov 20;2(6046):1227-9. doi: 10.1136/bmj.2.6046.1227.
Abstract
People with the variants of glucose-6-phosphate dehydrogenase (GPD) deficiency common in the southern Chinese (Canton, B(-)Chinese, and Hong Kong-Pokfulam) have a moderate shortening of red-cell survival but no anaemia when they are in the steady state. With a cross-transfusion technique, primaquine, nitrofurantoin, and large doses of aspirin were found to aggravate the haemolysis while sulphamethoxazole did so only in some people. Individual differences in drug metabolism may be the reason for this. Many commonly used drugs reported to accentuate haemolysis in GPD deficiency did not shorten red-cell survival.
摘要
在中国南方（广东、B(-)型中国人和香港薄扶林）常见的葡萄糖-6-磷酸脱氢酶（GPD）缺乏症变体携带者，其红细胞生存期会适度缩短，但在稳定状态下无贫血症状。采用交叉输血技术发现，伯氨喹、呋喃妥因和大剂量阿司匹林会加重溶血，而磺胺甲恶唑仅在部分人群中会加重溶血。药物代谢的个体差异可能是其原因。许多据报道会在GPD缺乏症中加重溶血的常用药物并未缩短红细胞生存期。
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