Schaller H C, Schmidt T, Flick K, Grimmelikhuijzen C J P
European Molecular Biology Laboratory, Postfach 10.2209, D-6900, Heidelberg, Germany.
Wilehm Roux Arch Dev Biol. 1977 Sep;183(3):193-206. doi: 10.1007/BF00867320.
A mutant ofHydra attenuata is analysed, theaberrant, which is distinct from the wild type in having a smaller head with fewer tentacles and only half the number of head-specific cells. The rate of head and foot regeneration and the doubling time are slower inaberrants than in normal hydra.The lower head-forming potential is paralleled by a reduced concentration of head-specific morphogens: compared to the wild type, in theaberrant the concentration of head activator is reduced to 70% in the head and to 50% in the body, the concentration of head inhibitor is reduced to 50% in the head and to 80% in the body. Theaberrant is more sensitive (3 times) to added head activator and less sensitive (>5 times) to added head inhibitor than the wild type.The slower rate of foot regeneration is paralleled by a lower content of foot-specific morphogens: compared to the wild type, in theaberrant the foot activator is reduced to 40% and the foot inhibitor to 70%.
对一种细弱水螅的突变体——异常体进行了分析，它与野生型不同，头部较小，触手较少，头部特异性细胞数量只有野生型的一半。异常体的头部和足部再生速率以及细胞倍增时间比正常水螅慢。较低的头部形成潜力与头部特异性形态发生素浓度降低相对应：与野生型相比，异常体中头部激活剂在头部的浓度降至70%，在身体中的浓度降至50%，头部抑制剂在头部的浓度降至50%，在身体中的浓度降至80%。与野生型相比，异常体对添加的头部激活剂更敏感（3倍），对添加的头部抑制剂不太敏感（>5倍）。足部再生速率较慢与足部特异性形态发生素含量较低相对应：与野生型相比，异常体中足部激活剂降至40%，足部抑制剂降至70%。
