超细氧化锌（Z-cote）作为一种光稳定的UVA/UVB防晒剂。
Microfine zinc oxide (Z-cote) as a photostable UVA/UVB sunblock agent.
作者信息
Mitchnick M A, Fairhurst D, Pinnell S R
机构信息
sunSmart Inc, Wainscott, New York, USA.
出版信息
J Am Acad Dermatol. 1999 Jan;40(1):85-90. doi: 10.1016/s0190-9622(99)70532-3.
BACKGROUND
Microfine zinc oxide (Z-Cote) is used as a transparent broad-spectrum sunblock to attenuate UV radiation (UVR), including UVA I (340-400 nm).
OBJECTIVE
Our purpose was to assess the suitability of microfine zinc oxide as a broad-spectrum photoprotective agent by examining those properties generally considered important in sunscreens: attenuation spectrum, sun protection factor (SPF) contribution, photostability, and photoreactivity.
METHODS
Attenuation spectrum was assessed by means of standard spectrophotometric methods. SPF contribution was evaluated according to Food and Drug Administration standards. Photostability was measured in vitro by assessing SPF before and after various doses of UVR. Photoreactivity was evaluated by subjecting a microfine zinc oxide/organic sunscreen formulation to escalating doses of UVR and determining the percentage of organic sunscreen remaining.
RESULTS
Microfine zinc oxide attenuates throughout the UVR spectrum, including UVA I. It is photostable and does not react with organic sunscreens under irradiation.
CONCLUSION
Microfine zinc oxide is an effective and safe sunblock that provides broad-spectrum UV protection, including protection from long-wavelength UVA.
背景
微细化氧化锌（Z-Cote）用作透明广谱防晒剂，以减弱紫外线辐射（UVR），包括UVA I（340 - 400纳米）。
目的
我们的目的是通过研究那些通常被认为在防晒剂中很重要的特性：衰减光谱、防晒系数（SPF）贡献、光稳定性和光反应性，来评估微细化氧化锌作为广谱光保护剂的适用性。
方法
通过标准分光光度法评估衰减光谱。根据食品药品监督管理局标准评估SPF贡献。通过评估不同剂量紫外线辐射前后的SPF在体外测量光稳定性。通过使微细化氧化锌/有机防晒剂配方接受递增剂量的紫外线辐射并测定剩余有机防晒剂的百分比来评估光反应性。
结果
微细化氧化锌在整个紫外线辐射光谱范围内，包括UVA I，都有衰减作用。它具有光稳定性，并且在照射下不与有机防晒剂发生反应。
结论
微细化氧化锌是一种有效且安全的防晒剂，可提供广谱紫外线防护，包括对长波长UVA的防护。
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