Sciubba J J, Waterhouse J P, Meyer J
J Oral Pathol. 1978 Aug;7(4):214-27. doi: 10.1111/j.1600-0714.1978.tb01596.x.
Incisional wounds of the same length and depth were made on tongue and dorsal skin of rats and the fine structural aspects of the responses of these were compared. Comparisons were made between the timing and degree of phagocytosis, the timing and rate of epithelial cell migration, of overall rate of healing, and of reformation of basal lamina and attachment complex in these two tissues. Phagocytic activity in epithelium and connective tissue of mucosa reached higher levels than in skin and the peak of activity in the epithelium of the mucosa was earlier than in the epidermis. Mononuclear phagocytes were active in phagocytosis, neutrophils showed little phagocytic activity. Epithelial migration was found to begin earlier in mucosa than in skin. Epithelialization of the wound and repair of supporting tissue were completed earlier. The same sequence in the renewal of ultrastructural components of the hemidesmosome-attachment complex was found in skin and mucosa, but was completed earlier at the mucosal site. Mechanical and physical as well as physiologic factors may play a role in determining the differing rates of repair in mucosa and skin.
在大鼠的舌头和背部皮肤制作长度和深度相同的切口伤口，并比较两者反应的精细结构方面。比较了吞噬作用的时间和程度、上皮细胞迁移的时间和速率、整体愈合速率以及这两种组织中基底层和附着复合体的重塑情况。黏膜上皮和结缔组织中的吞噬活性高于皮肤，黏膜上皮的活性峰值早于表皮。单核吞噬细胞在吞噬作用中活跃，中性粒细胞吞噬活性较低。发现黏膜上皮迁移比皮肤开始得早。伤口上皮化和支持组织修复完成得更早。在皮肤和黏膜中发现半桥粒-附着复合体超微结构成分更新的顺序相同，但在黏膜部位完成得更早。机械、物理以及生理因素可能在决定黏膜和皮肤不同修复速率中起作用。
