十二指肠溃疡患者在迷走神经干切断术前、后脂肪诱导的空肠对胃酸分泌的抑制作用。
Fat induced jejunal inhibition of gastric acid secretion in duodenal ulcer patients before and after truncal vagotomy.
作者信息
Christiansen J
出版信息
Ann Surg. 1977 Nov;186(5):573-6. doi: 10.1097/00000658-197711000-00005.
Abstract
The effect of intrajejunal infusion of a fat solution on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in five duodenal ulcer patients before and three to five months after truncal vagotomy. Preoperatively mean acid output was reduced from 41 +/- 5.2 meq H+/hr to 15.4 +/- 1.3 meq H+/hr (p less than 0.005), and postoperatively from 17.4 +/- 2.6 meq H+/hr to 12.7 +/- 2.4 meq H+/HR (P less than 0.01), demonstrating that fat induced jejunal inhibition of gastric acid secretion partly or wholly is humorally mediated. Furthermore the study shows that fat induced jejunal inhibition of acid secretion in duodenal ulcer patients seem to be of the same magnitude as previously found in healthy subjects.
摘要
在五名十二指肠溃疡患者行迷走神经切断术前及术后三至五个月，研究了空肠内输注脂肪溶液对五肽胃泌素刺激（0.5微克/千克·小时）胃酸分泌的影响。术前平均酸排量从41±5.2毫当量氢离子/小时降至15.4±1.3毫当量氢离子/小时（P＜0.005），术后从17.4±2.6毫当量氢离子/小时降至12.7±2.4毫当量氢离子/小时（P＜0.01），表明脂肪引起的空肠对胃酸分泌的抑制部分或完全是由体液介导的。此外，该研究表明，十二指肠溃疡患者中脂肪引起的空肠对酸分泌的抑制似乎与先前在健康受试者中发现的程度相同。
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本文引用的文献
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Gut. 1965 Jun;6(3):296-300. doi: 10.1136/gut.6.3.296.
2
THE VAGAL NERVE AND THE INTESTINAL PHASE OF GASTRIC SECRETION.迷走神经与胃分泌的肠期
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Surgery. 1970 Jul;68(1):202-7; discussion 207-8.
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Gastroenterology. 1970 Sep;59(3):364-71.
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