Haavik H I
Acta Pathol Microbiol Scand B. 1976 Jun;84(3):117-24. doi: 10.1111/j.1699-0463.1976.tb01913.x.
The inhibitory effect of bacitracin upon growth of the producer strain Bacillus licheniformis ATCC 10716 was dependent upon the presence of several different metal (II) ions, particularly Mn (II), Co (II), or Zn (II) ions. This supports our previous suggestion that the normal function of bacitracin during growth of the producer organism may be to promote the uptake of several divalent metal ions. Due to the striking similarity between the antimicrobial effect of bacitracin towards susceptible organisms and the effect of bacitracin towards the producer organisms B. licheniformis ATCC 10716, the possibility that the antimicrobial effect of bacitracin may be an induction of uptake of toxic amounts of metal ions is discussed. The possibility that peptide antibiotics may normally participate in ion transport during growth of producer organisms is also discussed.
杆菌肽对其产生菌地衣芽孢杆菌ATCC 10716生长的抑制作用取决于几种不同金属（II）离子的存在，特别是锰（II）、钴（II）或锌（II）离子。这支持了我们之前的推测，即杆菌肽在产生菌生长过程中的正常功能可能是促进几种二价金属离子的摄取。由于杆菌肽对敏感菌的抗菌作用与对产生菌地衣芽孢杆菌ATCC 10716的作用极为相似，因此讨论了杆菌肽的抗菌作用可能是诱导摄取有毒量金属离子的可能性。还讨论了肽类抗生素在产生菌生长过程中可能正常参与离子转运的可能性。
