Andersson S, Rosell S, Hjelmquist U, Chang D, Folkers K
Acta Physiol Scand. 1977 Jun;100(2):231-5. doi: 10.1111/j.1748-1716.1977.tb05941.x.
The action of (Gln4)-neurotensin was studied on the spontaneous motor activity in isolated canine fundic, antral and intestinal pouches. All pouches had been prepared more than 6 months prior to the experiments. Spontaneous motor activity was recorded for at least 1 h before the Gln4)-neurotensin was infused i.v. for 30 min in doses ranging between 6.3 and 100 ng X kg-1 X min-1. In the vagally denervated fundic pouches (Gln4)-neurotensin inhibted motor activity in doses above 25 ng X kg-1 X min-1. The vagally innervated antral pouches were more sentitive than the vagally denervated fundic pouches to the action of (Gln4)-neurotensin. Thus motor inhibition was induced by doses as low as 6.3 ng X kg-1 X min-1. The effect of (Gln4)-neurotensin on motor activity in intestinal pouches was inconsistent. Inhibition was seen in 1 out of 7 expts. The present results show that the gastric motor activity is the most sensitive function to (Gln4)-neurotensin so far studied.
研究了（Gln4）-神经降压素对离体犬胃底、胃窦和肠袋自发运动活性的作用。所有肠袋均在实验前6个月以上制备。在静脉注射（Gln4）-神经降压素30分钟之前，记录自发运动活性至少1小时，注射剂量范围为6.3至100 ng·kg-1·min-1。在迷走神经切断的胃底袋中，（Gln4）-神经降压素在剂量高于25 ng·kg-1·min-1时抑制运动活性。迷走神经支配的胃窦袋比迷走神经切断的胃底袋对（Gln4）-神经降压素的作用更敏感。因此，低至6.3 ng·kg-1·min-1的剂量即可诱导运动抑制。（Gln4）-神经降压素对肠袋运动活性的影响不一致。在7次实验中有1次出现抑制。目前的结果表明，胃运动活性是迄今为止所研究的对（Gln4）-神经降压素最敏感的功能。
