Borcić B, Kruzić V, Kaić B, Ljubin-Sternak S, Ljubicić M, Dobrovsak-Sourek V
Croatian National Institute of Public Health, Zagreb, Croatia.
Acta Med Croatica. 1998;52(4-5):229-33.
Eight years after the last case of poliomyelitis it was of a special interest to determine the immunity level of the Croatian population to polio and thus to evaluate the possible risk of the revival of this infection. For this purpose, 200 sera samples were collected from individuals of different age and place of residence. Neutralizing antibodies (NT) for all three polioviruses were searched for. Antibody titers of > or = 1:8 were considered positive. Results of the study showed some 75% of the study subjects to have antibodies to polio type 1 and 2, and some 83% to type 3. Only 4% of the sera tested had no NT antibodies to any of the three types. The lowest mean geometric antibody titer (GMT) was for polio type 3 (GMT3 = 19.4; reciprocal value) and somewhat higher for type 1 (GMT1 = 23.5) and type 2 (GMT2 = 22.6). When the antibody titers were related with the age of the subjects, they were found not to decline with age, which was ascribed to periodical boosters with vaccinal strains. It is stressed that, in spite of the eradication of poliomyelitis achieved in Croatia, compulsory vaccination of the children should be continued until its global eradication.
在最后一例脊髓灰质炎病例出现八年后，确定克罗地亚人群对脊髓灰质炎的免疫水平并评估这种感染再次流行的潜在风险具有特殊意义。为此，从不同年龄和居住地点的个体中收集了200份血清样本。检测了针对所有三种脊髓灰质炎病毒的中和抗体（NT）。抗体滴度≥1:8被视为阳性。研究结果显示，约75%的研究对象对1型和2型脊髓灰质炎有抗体，约83%对3型有抗体。仅4%的检测血清对三种类型中的任何一种都没有NT抗体。最低的平均几何抗体滴度（GMT）是针对3型脊髓灰质炎（GMT3 = 19.4；倒数），1型（GMT1 = 23.5）和2型（GMT2 = 22.6）略高。当抗体滴度与受试者年龄相关时，发现它们不会随年龄下降，这归因于疫苗株的定期加强接种。需要强调的是，尽管克罗地亚已实现脊髓灰质炎根除，但在全球根除之前，儿童的强制疫苗接种仍应继续。
