Shin D H, Kolker A E, Kass M A, Kaback M B, Becker B
Arch Ophthalmol. 1976 Dec;94(12):2059-60. doi: 10.1001/archopht.1976.03910040719002.
Nineteen patients with symmetrical ocular hypertension and symmetrical cupping of the optic nerves were made asymmetric with respect to intraocular pressure for one to five years by unilateral topical treatment with epinephrine hydrochloride. Development of glaucomatous visual field defects was observed in 32% of the untreated eyes and in none of the treated eyes (P less than .05). Progressive cupping of the optic nerve was noted in 53% of the untreated eyes and in 11% of the treated eyes (P less than .025). Evidence of glaucomatous damage was observed more frequently in subjects maintained on this regimen for longer periods and in subjects with initial horizontal cup/disc ratios greater than 0.4 (P less than .05). None of the eyes, either treated or untreated, with mean intraocular pressures less than 24 mm Hg developed glaucomatous damage during the period of this study.
19例患有对称性高眼压和视神经对称性杯状凹陷的患者，通过单侧局部应用盐酸肾上腺素使眼压不对称达1至5年。在未治疗的眼中，32%出现了青光眼性视野缺损，而治疗的眼中无一例出现（P小于0.05）。53%的未治疗眼和11%的治疗眼出现了视神经进行性杯状凹陷（P小于0.025）。在维持该治疗方案较长时间的受试者以及初始水平杯盘比大于0.4的受试者中，更频繁地观察到青光眼性损害的证据（P小于0.05）。在本研究期间，平均眼压低于24 mmHg的眼，无论治疗与否，均未出现青光眼性损害。
