[摩根氏变形杆菌的诱导型头孢菌素酶]

[Inducible cephalosporinases from Proteus morganii].

作者信息

Labia R, Guionie M, Fabre C

出版信息

Biochimie. 1976 Nov 13;58(9):1083-7. doi: 10.1016/s0300-9084(76)80086-7.

Abstract

It has been shown that two Proteus morganii strains produce an inducible cephalosporinase. No significative difference was shown between them: they present the same isoelectric poit: 8,3 and very similar kinetic constants. The parameter tau, proportional to the half life of antibiotic at low concentration, in presence of beta lactamase, shows that cefamandole is the most stable cephalosporin studied.

摘要

已表明两种摩根氏变形杆菌菌株可产生一种诱导型头孢菌素酶。它们之间未显示出显著差异：它们具有相同的等电点：8.3，且动力学常数非常相似。参数tau与低浓度抗生素在β-内酰胺酶存在时的半衰期成正比，表明头孢孟多是所研究的最稳定的头孢菌素。