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1
HR 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity.HR 756，一种具有独特抗菌活性的新型甲氧亚氨基头孢菌素的顺式异构体。
Antimicrob Agents Chemother. 1978 Nov;14(5):749-54. doi: 10.1128/AAC.14.5.749.
2
[Cefotaxime, syn isomer of a new methoxyimino cephalosporin with unusual activity (author's transl)].
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3
Evaluation of antibacterial activities of cephalosporin antibiotics: cefazolin, cephaloridine, cephalothin, and cephalexin.头孢菌素类抗生素的抗菌活性评估：头孢唑林、头孢噻啶、头孢噻吩和头孢氨苄。
Zhonghua Min Guo Wei Sheng Wu Xue Za Zhi. 1975 Mar;8(1):1-11.
4
Lytic activity of a new cephalosporin, cefuroxime, against gram-negative bacteria.新型头孢菌素头孢呋辛对革兰氏阴性菌的溶菌活性。
Chemotherapy. 1978;24(6):354-9. doi: 10.1159/000237807.
5
The in vitro spectrum of the cephalosporins.头孢菌素的体外抗菌谱。
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6
Comparative activities of cefotaxime, a new cephalosporin derivative, and of selected beta-lactam antibiotics against Haemophilus species.新型头孢菌素衍生物头孢噻肟与选定的β-内酰胺类抗生素对嗜血杆菌属的比较活性
Ann Microbiol (Paris). 1979 May-Jun;130 A(4):461-7.
7
[A comparative study of antibacterial activity of ceftibuten, ceftazidime, cefuroxime and ampicillin against clinical isolates].头孢布烯、头孢他啶、头孢呋辛和氨苄西林对临床分离株抗菌活性的比较研究
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9
In vitro and in vivo comparative evaluations of injectable cephalosporin derivatives and ampicillin.注射用头孢菌素衍生物与氨苄西林的体外和体内比较评价
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3-Deacetoxy-7-(alpha-amino-1-cyclohexenylacetamido) cephalosporanic acid (SCE-100), a new semisynthetic cephalosporin. I. Comparative in vitro antibacterial activities of SCE-100 and cephalexin (CEX).
J Antibiot (Tokyo). 1976 May;29(5):559-65. doi: 10.7164/antibiotics.29.559.

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2
Role of porin proteins OmpF and OmpC in the permeation of beta-lactams.孔蛋白OmpF和OmpC在β-内酰胺通透性中的作用。
Antimicrob Agents Chemother. 1982 Dec;22(6):942-8. doi: 10.1128/AAC.22.6.942.
3
The polar effect on nifM of mutations in the nifU,-S,-V genes of Klebsiella pneumoniae depends on their plasmid or chromosomal location.肺炎克雷伯菌nifU、-S、-V基因中突变对nifM的极性效应取决于它们的质粒或染色体位置。
Mol Gen Genet. 1982;186(4):569-71. doi: 10.1007/BF00337966.
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Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.莫西拉酸（LY127935），一种新型半合成1-氧杂-β-内酰胺抗生素，具有显著的抗菌活性：与头孢孟多和妥布霉素的体外比较。
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6
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7
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8
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9
In vitro antimicrobial activity of cefotaxime, a new cephalosporin.新型头孢菌素头孢噻肟的体外抗菌活性
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10
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Infection. 1980;8 Suppl 3:S 305-9. doi: 10.1007/BF01639601.

本文引用的文献

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Resistance of Escherichia coli to penicillins. V. Physiological comparison of two isogenic strains, one with chromosomally and one with episomally mediated ampicillin resistance.大肠杆菌对青霉素的耐药性。V. 两个同基因菌株的生理学比较，一个具有染色体介导的氨苄青霉素耐药性，另一个具有附加体介导的氨苄青霉素耐药性。
J Bacteriol. 1968 Aug;96(2):438-46. doi: 10.1128/jb.96.2.438-446.1968.
2
Incompatibility groups and the classification of fi - resistance factors.不相容性群与抗噬菌体因子的分类。
J Bacteriol. 1972 Nov;112(2):666-75. doi: 10.1128/jb.112.2.666-675.1972.
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[Kinetic study of 2 beta lactamases responsible for the same phenotype].
Biochimie. 1974;56(8):1025-30. doi: 10.1016/s0300-9084(74)80092-1.
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R-factor-mediated beta-lactamases that hydrolyze oxacillin: evidence for two distinct groups.R因子介导的可水解苯唑西林的β-内酰胺酶：两个不同组别的证据。
J Bacteriol. 1974 Aug;119(2):351-6. doi: 10.1128/jb.119.2.351-356.1974.
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R factor-mediated and chromosomal resistance to ampicillin in Escherichia coli.大肠杆菌中R因子介导的及染色体介导的对氨苄青霉素的耐药性
Antimicrob Agents Chemother. 1974 Feb;5(2):186-91. doi: 10.1128/AAC.5.2.186.
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Comparison of the substrate specificities of the -lactamases from Klebsiella aerogenes 1082E and Enterobacter cloacae P99.产气克雷伯菌1082E和阴沟肠杆菌P99的β-内酰胺酶底物特异性比较。
Appl Microbiol. 1972 Apr;23(4):765-9. doi: 10.1128/am.23.4.765-769.1972.
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Relation of beta-lactamase activity and cellular location to resistance of Enterobacter to penicillins and cephalosporins.β-内酰胺酶活性及细胞定位与肠杆菌对青霉素和头孢菌素耐药性的关系。
Antimicrob Agents Chemother. 1972 Feb;1(2):107-11. doi: 10.1128/AAC.1.2.107.
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Computerized microacidimetric determination of beta lactamase Michaelis-Menten constants.β-内酰胺酶米氏常数的计算机化微酸量滴定法测定
FEBS Lett. 1973 Jun 15;33(1):42-4. doi: 10.1016/0014-5793(73)80154-1.
9
Antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cefamandole.新型头孢菌素抗生素头孢呋辛与头孢噻啶、头孢噻吩和头孢孟多的抗菌活性比较。
Antimicrob Agents Chemother. 1976 Apr;9(4):690-5. doi: 10.1128/AAC.9.4.690.
10
Cefuroxime, a new cephalosporin antibiotic: activity in vitro.头孢呋辛，一种新型头孢菌素抗生素：体外活性
Antimicrob Agents Chemother. 1976 Mar;9(3):511-9. doi: 10.1128/AAC.9.3.511.

HR 756，一种具有独特抗菌活性的新型甲氧亚氨基头孢菌素的顺式异构体。

HR 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity.

作者信息

Chabbert Y A, Lutz A J

出版信息

Antimicrob Agents Chemother. 1978 Nov;14(5):749-54. doi: 10.1128/AAC.14.5.749.

DOI:10.1128/AAC.14.5.749
PMID:31836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352545/
Abstract

HR 756, the syn derivative of 7-[(2-(2-amino-4-thiazolyl)-2-methoxyimino)acetamido]cephalosporanic acid, is a new semisynthetic cephalosporin. It was 80 times more active than the anti derivative against beta-lactamase-producing strains of gram-negative bacteria. The range of inhibitory concentrations of HR 756 against gram-negative bacteria, including Haemophilus influenzae, susceptible or resistant to penicillins and cephalosporins was from 0.01 to 0.1 mug/ml. This activity was consistently higher than those observed with cephalothin, cephaloridine, cephalexin, and cefazolin. Nevertheless, some strains of Enterobacter cloacae were resistant. HR 756 showed very similar activity to that of ampicillin against group A streptococci and Streptococcus pneumoniae.

摘要

HR 756是7-[(2-(2-氨基-4-噻唑基)-2-甲氧基亚氨基)乙酰胺基]头孢烷酸的合成衍生物，是一种新型半合成头孢菌素。它对产生β-内酰胺酶的革兰氏阴性菌的活性比其反式衍生物高80倍。HR 756对革兰氏阴性菌（包括对青霉素和头孢菌素敏感或耐药的流感嗜血杆菌）的抑制浓度范围为0.01至0.1微克/毫升。该活性始终高于头孢噻吩、头孢噻啶、头孢氨苄和头孢唑林。然而，一些阴沟肠杆菌菌株具有耐药性。HR 756对A组链球菌和肺炎链球菌的活性与氨苄西林非常相似。