HR 756，一种具有独特抗菌活性的新型甲氧亚氨基头孢菌素的顺式异构体。
HR 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity.
作者信息
Chabbert Y A, Lutz A J
出版信息
Antimicrob Agents Chemother. 1978 Nov;14(5):749-54. doi: 10.1128/AAC.14.5.749.
Abstract
HR 756, the syn derivative of 7-[(2-(2-amino-4-thiazolyl)-2-methoxyimino)acetamido]cephalosporanic acid, is a new semisynthetic cephalosporin. It was 80 times more active than the anti derivative against beta-lactamase-producing strains of gram-negative bacteria. The range of inhibitory concentrations of HR 756 against gram-negative bacteria, including Haemophilus influenzae, susceptible or resistant to penicillins and cephalosporins was from 0.01 to 0.1 mug/ml. This activity was consistently higher than those observed with cephalothin, cephaloridine, cephalexin, and cefazolin. Nevertheless, some strains of Enterobacter cloacae were resistant. HR 756 showed very similar activity to that of ampicillin against group A streptococci and Streptococcus pneumoniae.
摘要
HR 756是7-[(2-(2-氨基-4-噻唑基)-2-甲氧基亚氨基)乙酰胺基]头孢烷酸的合成衍生物，是一种新型半合成头孢菌素。它对产生β-内酰胺酶的革兰氏阴性菌的活性比其反式衍生物高80倍。HR 756对革兰氏阴性菌（包括对青霉素和头孢菌素敏感或耐药的流感嗜血杆菌）的抑制浓度范围为0.01至0.1微克/毫升。该活性始终高于头孢噻吩、头孢噻啶、头孢氨苄和头孢唑林。然而，一些阴沟肠杆菌菌株具有耐药性。HR 756对A组链球菌和肺炎链球菌的活性与氨苄西林非常相似。
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