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1
Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates.鼠伤寒沙门氏菌和脂多糖通过一种涉及磷脂酰肌醇3激酶和磷脂酶D作为新中间体的机制刺激巨噬细胞中的细胞外调节激酶激活。
Infect Immun. 1999 Mar;67(3):1011-7. doi: 10.1128/IAI.67.3.1011-1017.1999.
2
Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C.脂多糖通过一种新的不依赖Cdc42/Rac的途径在巨噬细胞中诱导Jun N端激酶激活，该途径涉及蛋白激酶C zeta和磷脂酰胆碱依赖性磷脂酶C的顺序激活。
Blood. 2000 Oct 1;96(7):2592-8.
3
Distinct mechanisms target stress and extracellular signal-activated kinase 1 and Jun N-terminal kinase during infection of macrophages with Salmonella.在巨噬细胞被沙门氏菌感染期间，不同的机制作用于应激和细胞外信号调节激酶1以及Jun氨基末端激酶。
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4
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.细菌脂多糖刺激的巨噬细胞中c-Jun氨基末端激酶的激活
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2774-8. doi: 10.1073/pnas.93.7.2774.
5
Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes.G蛋白利用一条新的不依赖βγ和Ras的途径来激活细胞外信号调节激酶，并在Jurkat T淋巴细胞中调动AP-1转录因子。
J Biol Chem. 1999 Jul 9;274(28):19992-20001. doi: 10.1074/jbc.274.28.19992.
6
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.凝血酶诱导人培养气管平滑肌细胞中与细胞增殖相关的丝裂原活化蛋白激酶（MAPK）激活的机制
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7
Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages.脂多糖诱导的促分裂原诱导型环氧化酶的表达：通过丝裂原活化蛋白激酶和核因子κB信号通路在巨噬细胞中介导。
Biochem Pharmacol. 1997 Jul 1;54(1):87-96. doi: 10.1016/s0006-2952(97)00154-8.
8
TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway.肿瘤坏死因子-α诱导人肺上皮细胞中环氧化酶-2的表达：磷脂酶C-γ2、蛋白激酶C-α、酪氨酸激酶、核因子-κB诱导激酶及I-κB激酶1/2信号通路的参与
J Immunol. 2000 Sep 1;165(5):2719-28. doi: 10.4049/jimmunol.165.5.2719.
9
Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity.脂多糖激活巨噬细胞中的杀肿瘤特性需要蛋白酪氨酸激酶活性。
J Leukoc Biol. 1993 Jan;53(1):53-60. doi: 10.1002/jlb.53.1.53.
10
Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.细菌脂多糖诱导巨噬细胞中酪氨酸磷酸化并激活丝裂原活化蛋白激酶。
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IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton.IQGAP1 在微生物发病机制中的作用：靶向肌动蛋白细胞骨架。
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Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase.巨噬细胞对嗜肺军团菌的非调理吞噬作用由磷脂酰肌醇3激酶介导。
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Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines.莫西沙星对活化的人单核细胞的抗炎作用：抑制核因子κB和丝裂原活化蛋白激酶的激活以及促炎细胞因子的合成。
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本文引用的文献

1
Growth phase-regulated induction of Salmonella-induced macrophage apoptosis correlates with transient expression of SPI-1 genes.沙门氏菌诱导的巨噬细胞凋亡的生长阶段调节诱导与SPI-1基因的瞬时表达相关。
J Bacteriol. 1999 Jun;181(11):3433-7. doi: 10.1128/JB.181.11.3433-3437.1999.
2
Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.由磷脂酰肌醇3-激酶活性调节的下游信号事件。
Cell Signal. 1998 Apr;10(4):233-9. doi: 10.1016/s0898-6568(97)00129-0.
3
Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells.丝裂原活化蛋白激酶途径参与鼠伤寒沙门氏菌诱导培养的肠上皮细胞的核反应和细胞因子产生。
J Immunol. 1997 Dec 1;159(11):5550-9.
4
Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen-activated protein kinase pathway.单核细胞增生李斯特菌侵袭上皮细胞需要MEK-1/ERK-2丝裂原活化蛋白激酶途径。
Infect Immun. 1998 Mar;66(3):1106-12. doi: 10.1128/IAI.66.3.1106-1112.1998.
5
Involvement of MAP-kinases and -phosphatases in uptake and intracellular replication of Listeria monocytogenes in J774 macrophage cells.丝裂原活化蛋白激酶和磷酸酶在J774巨噬细胞中单核细胞增生李斯特菌的摄取及细胞内复制中的作用。
FEMS Microbiol Lett. 1997 Dec 1;157(1):131-6. doi: 10.1111/j.1574-6968.1997.tb12763.x.
6
Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors.通过G蛋白偶联受体对丝裂原活化蛋白激酶级联反应的细胞外信号调节激酶亚组进行调控。
Cell Signal. 1997 Aug;9(5):337-51. doi: 10.1016/s0898-6568(96)00191-x.
7
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes.白细胞中膜皱褶形成和吞噬作用对Rac1和Cdc42的需求。
J Exp Med. 1997 Nov 3;186(9):1487-94. doi: 10.1084/jem.186.9.1487.
8
Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength.渥曼青霉素对丝裂原活化蛋白激酶级联反应的条件性抑制。对信号强度的依赖性。
J Biol Chem. 1997 Oct 31;272(44):27665-70. doi: 10.1074/jbc.272.44.27665.
9
How Salmonella became a pathogen.沙门氏菌是如何成为一种病原体的。
Trends Microbiol. 1997 Sep;5(9):343-9. doi: 10.1016/S0966-842X(97)01099-8.
10
Rho is required for the initiation of calcium signaling and phagocytosis by Fcgamma receptors in macrophages.Rho对于巨噬细胞中Fcγ受体引发钙信号传导和吞噬作用是必需的。
J Exp Med. 1997 Sep 15;186(6):955-66. doi: 10.1084/jem.186.6.955.

鼠伤寒沙门氏菌和脂多糖通过一种涉及磷脂酰肌醇3激酶和磷脂酶D作为新中间体的机制刺激巨噬细胞中的细胞外调节激酶激活。

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates.

作者信息

Procyk K J, Kovarik P, von Gabain A, Baccarini M

机构信息

Department of Cell and Microbiology, Institute of Microbiology and Genetics, Vienna Biocenter, 1030 Vienna, Austria.

出版信息

Infect Immun. 1999 Mar;67(3):1011-7. doi: 10.1128/IAI.67.3.1011-1017.1999.

DOI:10.1128/IAI.67.3.1011-1017.1999
PMID:10024537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC96423/
Abstract

Activation of the extracellularly regulated kinase (ERK) pathway is part of the early biochemical events that follow lipopolysaccharide (LPS) treatment of macrophages or their infection by virulent and attenuated Salmonella strains. Phagocytosis as well as the secretion of invasion-associated proteins is dispensable for ERK activation by the pathogen. Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS. Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. Phospholipase D activation and stimulation of protein kinase C appear to be intermediates in this novel pathway of MEK/ERK activation.

摘要

细胞外调节激酶（ERK）途径的激活是巨噬细胞经脂多糖（LPS）处理或被强毒和减毒沙门氏菌菌株感染后早期生化事件的一部分。病原体激活ERK无需吞噬作用以及侵袭相关蛋白的分泌。此外，沙门氏菌和LPS刺激ERK所使用的途径相同，这表明激酶激活可能仅由LPS介导。两种刺激均通过涉及除草霉素依赖性酪氨酸激酶和磷脂酰肌醇3激酶的机制激活ERK。磷脂酶D的激活和蛋白激酶C的刺激似乎是MEK/ERK激活这一新途径的中间环节。