• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Kinetic and chemical mechanism of epoxide hydrolase.

作者信息

Armstrong R N

机构信息

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

出版信息

Drug Metab Rev. 1999 Feb;31(1):71-86. doi: 10.1081/dmr-100101908.

DOI:10.1081/dmr-100101908
PMID:10065366
Abstract
摘要

相似文献

1
Kinetic and chemical mechanism of epoxide hydrolase.环氧水解酶的动力学和化学机制。
Drug Metab Rev. 1999 Feb;31(1):71-86. doi: 10.1081/dmr-100101908.
2
Epoxide hydrolase-catalyzed enantioselective conversion of trans-stilbene oxide: Insights into the reaction mechanism from steady-state and pre-steady-state enzyme kinetics.环氧水解酶催化反式氧化芪的对映选择性转化：从稳态和预稳态酶动力学洞察反应机制
Arch Biochem Biophys. 2016 Feb 1;591:66-75. doi: 10.1016/j.abb.2015.12.008. Epub 2015 Dec 20.
3
Theoretical study of the full reaction mechanism of human soluble epoxide hydrolase.人可溶性环氧化物水解酶全反应机制的理论研究
Chemistry. 2006 Sep 6;12(26):6898-909. doi: 10.1002/chem.200501519.
4
Microbial epoxide hydrolases for preparative biotransformations.用于制备性生物转化的微生物环氧化物水解酶。
Curr Opin Biotechnol. 2001 Dec;12(6):552-8. doi: 10.1016/s0958-1669(01)00262-2.
5
Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution.通过定向进化提高环氧水解酶的对映选择性。
Org Lett. 2004 Jan 22;6(2):177-80. doi: 10.1021/ol035898m.
6
Fungal epoxide hydrolases: new landmarks in sequence-activity space.真菌环氧化物水解酶：序列-活性空间中的新地标
Trends Biotechnol. 2004 Mar;22(3):123-9. doi: 10.1016/j.tibtech.2004.01.012.
7
Kinetic mechanism of the enantioselective conversion of styrene oxide by epoxide hydrolase from Agrobacterium radiobacter AD1.放射形土壤杆菌AD1环氧水解酶对苯乙烯氧化物对映选择性转化的动力学机制
Biochemistry. 1998 Dec 22;37(51):18119-27. doi: 10.1021/bi9817257.
8
Insights into the reaction mechanism of soluble epoxide hydrolase from theoretical active site mutants.基于理论活性位点突变体对可溶性环氧化物水解酶反应机制的深入研究
J Phys Chem B. 2006 Oct 26;110(42):21299-310. doi: 10.1021/jp063830t.
9
Structure of Aspergillus niger epoxide hydrolase at 1.8 A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases.黑曲霉环氧化物水解酶在1.8埃分辨率下的结构：对哺乳动物微粒体类环氧化物水解酶结构与功能的启示
Structure. 2000 Feb 15;8(2):111-22. doi: 10.1016/s0969-2126(00)00087-3.
10
Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates.微粒体环氧化物水解酶而非胆固醇环氧化物水解酶与其底物之间共价中间体的可视化。
Eur J Biochem. 1997 Apr 15;245(2):490-6. doi: 10.1111/j.1432-1033.1997.00490.x.

引用本文的文献

1
Fungi, a neglected component of acidophilic biofilms: do they have a potential for biotechnology?真菌，嗜酸生物膜中被忽视的组成部分：它们具有生物技术潜力吗？
Extremophiles. 2019 May;23(3):267-275. doi: 10.1007/s00792-019-01085-9. Epub 2019 Mar 6.
2
Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium.探索巨大芽孢杆菌可溶性环氧化物水解酶选择性的起源。
Org Biomol Chem. 2017 Oct 25;15(41):8827-8835. doi: 10.1039/c7ob01847a.
3
In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s.
口服蛋白酶体抑制剂奥布佐米的体外代谢：环氧水解酶和细胞色素P450的作用
Drug Metab Dispos. 2017 Jul;45(7):712-720. doi: 10.1124/dmd.117.075226. Epub 2017 Apr 20.
4
Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.可视化细菌毒力酶Cif催化环氧化物水解的机制
Biochemistry. 2016 Feb 9;55(5):788-97. doi: 10.1021/acs.biochem.5b01229. Epub 2016 Jan 22.
5
Screening of epoxide hydrolase producing microorganisms for biotransformation of deoxynivalenol.筛选产环氧化物水解酶的微生物用于脱氧雪腐镰刀菌烯醇的生物转化。
Mycotoxin Res. 2005 Mar;21(1):71-3. doi: 10.1007/BF02954823.
6
Detoxication strategy of epoxide hydrolase-the basis for a novel threshold for definable genotoxic carcinogens.环氧化物水解酶的解毒策略——可定义遗传毒性致癌物新阈值的基础
Nonlinearity Biol Toxicol Med. 2004 Jan;2(1):21-6. doi: 10.1080/15401420490426963.
7
Homology modeling of a novel epoxide hydrolase (EH) from Aspergillus niger SQ-6: structure-activity relationship in expoxides inhibiting EH activity.黑曲霉SQ-6新型环氧水解酶（EH）的同源性建模：环氧物抑制EH活性的构效关系
J Mol Model. 2009 Sep;15(9):1125-32. doi: 10.1007/s00894-009-0466-5. Epub 2009 Feb 21.
8
Cloning and molecular characterization of a soluble epoxide hydrolase from Aspergillus niger that is related to mammalian microsomal epoxide hydrolase.黑曲霉中一种与哺乳动物微粒体环氧化物水解酶相关的可溶性环氧化物水解酶的克隆与分子特征分析
Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):273-80. doi: 10.1042/0264-6021:3440273.
9
Potent urea and carbamate inhibitors of soluble epoxide hydrolases.可溶性环氧化物水解酶的强效尿素和氨基甲酸酯抑制剂。
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8849-54. doi: 10.1073/pnas.96.16.8849.