Braito A, Ciufolini M G, Pippi L, Corbisiero R, Fiorentini C, Gistri A, Toscano L
Institute for Infectious Diseases, Siena University, Italy.
Scand J Infect Dis. 1998;30(5):505-8. doi: 10.1080/00365549850161539.
Toscana virus (TOSv) is a recently discovered Phlebotomus-transmitted human pathogen involved in acute infections of the central nervous system (CNS) occurring during the summer in natural foci in Italy. The purpose of this prospective study was to investigate the role of this virus in 170 patients with meningitis-meningoencephalitis of suspected viral origin, admitted to the Departments of Infectious Diseases at the Siena Hospital from 1990 to 1996. Infections caused by tick-borne encephalitis virus (TBEv) and TOSv or other neurotropic viruses were routinely diagnosed by means of conventional virological methods. 89 cases were attributed to TOSv, about 10% of which were Europeans on vacation in Tuscany. All of the TOSv-positive cases were observed during the summer and were residents of hilly areas in Siena and its province at an altitude not above 500 m. An increase in the number of cases was observed over the years, with a higher incidence among younger people. The clinical picture was similar to that observed in other viral infections of the CNS. Evolution was benign in all cases; in 2 subjects symptoms and signs of encephalitis were present.
托斯卡纳病毒（TOSv）是一种最近发现的由白蛉传播的人类病原体，与意大利自然疫源地夏季发生的中枢神经系统（CNS）急性感染有关。这项前瞻性研究的目的是调查该病毒在1990年至1996年期间入住锡耶纳医院传染病科的170例疑似病毒源性脑膜炎-脑膜脑炎患者中的作用。通过常规病毒学方法对蜱传脑炎病毒（TBEv）、TOSv或其他嗜神经病毒引起的感染进行常规诊断。89例病例归因于TOSv，其中约10%是在托斯卡纳度假的欧洲人。所有TOSv阳性病例均在夏季观察到，并且是锡耶纳及其省份海拔不超过500米的山区居民。多年来观察到病例数量有所增加，年轻人中的发病率更高。临床症状与在其他中枢神经系统病毒感染中观察到的相似。所有病例的病情演变均为良性；2名患者出现了脑炎的症状和体征。
