一项关于前列腺癌风险与前列腺癌家族史关系的病例队列研究。

A case-cohort study on prostate cancer risk in relation to family history of prostate cancer.

作者信息

Schuurman A G, Zeegers M P, Goldbohm R A, van den Brandt P A

机构信息

Department of Epidemiology, Maastricht University, The Netherlands.

出版信息

Epidemiology. 1999 Mar;10(2):192-5.

PMID:10069259

Abstract

We investigated the risk of prostate cancer in relation to a family history of prostate cancer in 58,279 men ages 55-69 years. We found 704 incident cases after 6.3 years of follow-up. Rate ratios and 95% confidence intervals for having an affected vs nonaffected father and brother were, respectively 1.44 (0.80-2.58) and 5.57 (1.61-19.26). We found no evidence for an increasing risk with an increasing percentage of affected family members. The associations we observed were stronger for cases diagnosed before age 70 compared with cases diagnosed after age 70 and for advanced compared with localized tumors.

摘要

我们对58279名年龄在55至69岁之间的男性进行了研究，以探讨前列腺癌风险与前列腺癌家族史之间的关系。经过6.3年的随访，我们发现了704例新发病例。有患病父亲与无患病父亲、有患病兄弟与无患病兄弟的发病率比值及95%置信区间分别为1.44（0.80 - 2.58）和5.57（1.61 - 19.26）。我们没有发现随着受影响家庭成员比例增加风险也增加的证据。我们观察到的关联在70岁之前诊断的病例中比70岁之后诊断的病例更强，在晚期肿瘤中比局限性肿瘤更强。