来自肋状纵胞藻的卤化单萜及其生物活性1。

Halogenated monoterpenes from plocamium costatum and their biological activity1.

作者信息

Konig GM, Wright AD

机构信息

Institute for Pharmaceutical Biology, Technical University Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany, and Centre for Marine Biofouling & Bio-Innovation, University of New South Wales, Sydney, New South Wales 2052, Aus.

出版信息

J Nat Prod. 1999 Feb;62(2):383-5. doi: 10.1021/np980408y.

DOI:10.1021/np980408y

PMID:10075796

Abstract

From the dichloromethane solubles of the temperate red alga Plocamium costatum, one new [1,4-dibromo-2,3,6-trichloro-3, 7-dimethyl-7-octene] (1) and three previously reported polyhalogenated monoterpenes (2-4), and the known phytol derivative 3,7,11,15-tetramethylhexadec-1-en-3-ol (1-phyten-3-ol, 5) were isolated. The structure of 1 was deduced from its spectroscopic data. For compound 3, complete 1H and 13C NMR data are reported for the first time. The CH2Cl2 extract and compounds 3 and 5 deterred settlement of barnacle larvae, suggesting a potential ecological role of these isolates.

摘要

从温带红藻Plocamium costatum的二氯甲烷可溶物中，分离出一种新的1,4 - 二溴 - 2,3,6 - 三氯 - 3,7 - 二甲基 - 7 - 辛烯和三种先前报道的多卤代单萜(2 - 4)，以及已知的植物醇衍生物3,7,11,15 - 四甲基十六 - 1 - 烯 - 3 - 醇(1 - 植烯 - 3 - 醇，5)。1的结构通过其光谱数据推导得出。对于化合物3，首次报道了完整的1H和13C NMR数据。二氯甲烷提取物以及化合物3和5可抑制藤壶幼虫的附着，表明这些分离物具有潜在的生态作用。