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黑腹果蝇中淀粉酶结构基因组织特异性表达的遗传调控。

Genetic regulation of tissue-specific expression of amylase structural genes in Drosophila melanogaster.

作者信息

Abraham I, Doane W W

出版信息

Proc Natl Acad Sci U S A. 1978 Sep;75(9):4446-50. doi: 10.1073/pnas.75.9.4446.

DOI:10.1073/pnas.75.9.4446
PMID:100784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336132/
Abstract

Laboratory strains of Drosophila melanogaster were screened for spatial variations in adult midgut alpha-amylase (1,4-alpha-D-glucan glucanohydrolase, EC 3.2.1.1) expression. No strain-specific differences were found anteriorly, but three patterns of activity were discerned in the posterior midgut: A, activity throughout most of the region; B, activity in the anterior part of the region; and C, little or no activity. Alleles of a control gene, map, are responsible for this tissue-specific regulation of activity; e.g., mapA homozygotes produce the A pattern and mapC homozygotes the C pattern. The map locus was placed at 2--80 +/- on the genetic map of chromosome 2R, about two crossover units distal to the Amy structural gene region for alpha-amylase. Electrophoretic studies showed that mapA is trans acting in mapA/mapC flies, allowing expression of amylase isozymes coded for by genes on the opposite chromosome. The map gene behaves as a temporal gene that is clearly separable from the tightly linked, duplicated Amy structural genes.

摘要

对黑腹果蝇的实验室菌株进行了筛选，以检测成年中肠α-淀粉酶（1,4-α-D-葡聚糖葡聚糖水解酶，EC 3.2.1.1）表达的空间差异。在前部未发现菌株特异性差异，但在后肠中发现了三种活性模式：A，在该区域的大部分区域有活性；B，在该区域的前部有活性；C，几乎没有或没有活性。一个对照基因map的等位基因负责这种组织特异性的活性调节；例如，mapA纯合子产生A模式，mapC纯合子产生C模式。map基因座位于2号染色体2R的遗传图谱上的2-80±处，距离α-淀粉酶的Amy结构基因区域约两个交换单位远。电泳研究表明，mapA在mapA/mapC果蝇中起反式作用，允许表达由相反染色体上的基因编码的淀粉酶同工酶。map基因表现为一个时间基因，与紧密连锁的、重复的Amy结构基因明显可分离。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ade/336132/284670af6345/pnas00668-0387-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ade/336132/25fa8218cf1e/pnas00668-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ade/336132/38259ec9b06a/pnas00668-0386-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ade/336132/284670af6345/pnas00668-0387-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ade/336132/25fa8218cf1e/pnas00668-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ade/336132/38259ec9b06a/pnas00668-0386-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ade/336132/284670af6345/pnas00668-0387-a.jpg

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本文引用的文献

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