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Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

作者信息

Hengartner H, Meo T, Müller E

出版信息

Proc Natl Acad Sci U S A. 1978 Sep;75(9):4494-8. doi: 10.1073/pnas.75.9.4494.

DOI:10.1073/pnas.75.9.4494
PMID:100785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336142/
Abstract

Using somatic cell hybrids from fusions of lymphocytes of two different mouse stocks with the myeloma cell line X63-Ag8, we have assigned genes for the immunoglobulin heavy and kappa-type light chains to chromosomes 12 and 6, respectively. The two mouse stocks exhibit karyotypes consisting of nine pairs of metacentric chromosomes as a result of centric fusions of acrocentric chromosomes in different combinations. In the hybrid cells these metacentric chromosomes can be distinguished from the acrocentric chromosomes of myeloma origin, permitting correlation of Ig chain expression with mitotic loss of individual metacentric chromosomes.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/841f8516d9ac/pnas00668-0435-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/055f229fd0f9/pnas00668-0433-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/8f9f02a21889/pnas00668-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/d6d61135af0a/pnas00668-0435-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/7d0885383b31/pnas00668-0435-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/45b63d1fd643/pnas00668-0435-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/841f8516d9ac/pnas00668-0435-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/055f229fd0f9/pnas00668-0433-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/8f9f02a21889/pnas00668-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/d6d61135af0a/pnas00668-0435-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/7d0885383b31/pnas00668-0435-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/45b63d1fd643/pnas00668-0435-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ba5/336142/841f8516d9ac/pnas00668-0435-d.jpg

相似文献

1
Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4494-8. doi: 10.1073/pnas.75.9.4494.
2
Organization and expression of immunoglobulin genes in fetal liver hybridomas.胎儿肝脏杂交瘤中免疫球蛋白基因的组织与表达
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Reorganization and expression of immunoglobulin genes: status of allelic elements.免疫球蛋白基因的重组与表达：等位基因元件的状态
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4
Mapping of the genes for mouse immunoglobulins M and D.小鼠免疫球蛋白M和D基因的定位
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Allelic variants of rearranged immunoglobulin heavy and light chain genes in hybridoma PTF-02 and parent myeloma.杂交瘤PTF-02和亲本骨髓瘤中重排免疫球蛋白重链和轻链基因的等位基因变体。
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Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.将克隆的免疫球蛋白重链和轻链基因转染至淋巴细胞后功能性免疫球蛋白M的产生。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6351-5. doi: 10.1073/pnas.80.20.6351.

引用本文的文献

1
Fusion of DNA region to murine immunoglobulin heavy chain locus corresponds to plasmacytoma-associated chromosome translocation.DNA区域与小鼠免疫球蛋白重链基因座的融合对应于浆细胞瘤相关的染色体易位。
EMBO J. 1983;2(2):213-6. doi: 10.1002/j.1460-2075.1983.tb01407.x.
2
Cell cycle kinetics of the accumulation of heavy and light chain immunoglobulin proteins in a mouse hybridoma cell line.小鼠杂交瘤细胞系中重链和轻链免疫球蛋白蛋白积累的细胞周期动力学。
Cytotechnology. 1994;14(3):205-18. doi: 10.1007/BF00749617.
3
Chromosome assignment of the tumor-specific antigen of a 3-methylcholanthrene-induced mouse sarcoma.

本文引用的文献

1
SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.体外成纤维细胞交配产生的杂种及其假定重组体的选择
Science. 1964 Aug 14;145(3633):709-10. doi: 10.1126/science.145.3633.709.
2
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
3
Intracellular immunoglobulin chain synthesis in non-secreting variants of a mouse myeloma: detection of inactive light-chain messenger RNA.
3-甲基胆蒽诱导的小鼠肉瘤肿瘤特异性抗原的染色体定位
J Exp Med. 1981 Sep 1;154(3):964-77. doi: 10.1084/jem.154.3.964.
4
Conserved regions of homologous G-banded chromosomes between orders in mammalian evolution: carnivores and primates.哺乳动物进化中不同目之间同源G带染色体的保守区域：食肉目和灵长目。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6631-5. doi: 10.1073/pnas.79.21.6631.
5
Allelic exclusion of immunoglobulin expression is not caused by somatic segregation.免疫球蛋白表达的等位基因排斥并非由体细胞分离所致。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):606-7. doi: 10.1073/pnas.79.2.606.
6
Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes.一个克隆的B细胞淋巴瘤同时表达免疫球蛋白μ链和δ重链：两个相邻的CH基因共享一个VH基因单拷贝。
Proc Natl Acad Sci U S A. 1982 May;79(9):2996-3000. doi: 10.1073/pnas.79.9.2996.
7
Human b-cell differentiation. I. Analysis of immunoglobulin heavy chain switching using monoclonal anti-immunoglobulin M, G, and A antibodies and pokeweed mitogen-induced plasma cell differentiation.人类B细胞分化。I. 使用单克隆抗免疫球蛋白M、G和A抗体以及商陆有丝分裂原诱导的浆细胞分化分析免疫球蛋白重链转换。
J Exp Med. 1982 Mar 1;155(3):839-51. doi: 10.1084/jem.155.3.839.
8
Sequence diversity within a subgroup of mouse immunoglobulin kappa chains controlled by the IgK-Ef2 locus.由IgK-Ef2基因座控制的小鼠免疫球蛋白κ链亚组内的序列多样性。
J Exp Med. 1981 Jul 1;154(1):146-55. doi: 10.1084/jem.154.1.146.
9
Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.克隆小鼠淋巴系不同细胞中μ和γ免疫球蛋白重链的表达
Proc Natl Acad Sci U S A. 1981 Jan;78(1):564-8. doi: 10.1073/pnas.78.1.564.
10
Simultaneous expression of mouse immunoglobulins M and D is determined by the same homolog of chromosome 12.小鼠免疫球蛋白M和D的同时表达由12号染色体的同系物决定。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6793-6. doi: 10.1073/pnas.77.11.6793.
小鼠骨髓瘤非分泌型变体中的细胞内免疫球蛋白链合成：无活性轻链信使核糖核酸的检测
J Mol Biol. 1974 Dec 25;90(4):691-701. doi: 10.1016/0022-2836(74)90533-6.
4
Robertsonian metacentrics in the mouse.小鼠中的罗伯逊中着丝粒染色体
Chromosoma. 1976 Nov 29;58(4):341-53. doi: 10.1007/BF00292842.
5
Characterization of the domestic horse (Equus caballus) karyotype using G- and C-banding techniques.
Experientia. 1976 Sep 15;32(9):1146-9. doi: 10.1007/BF01927593.
6
Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion.通过细胞融合获得产生特异性抗体的组织培养细胞系和肿瘤细胞系。
Eur J Immunol. 1976 Jul;6(7):511-9. doi: 10.1002/eji.1830060713.
7
Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines.免疫球蛋白分泌型与非分泌型骨髓瘤细胞系之间的融合。
Eur J Immunol. 1976 Apr;6(4):292-5. doi: 10.1002/eji.1830060411.
8
Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse.免疫球蛋白重链基因和血清前白蛋白基因在小鼠中是连锁的。
Nature. 1975 Aug 21;256(5519):644-6. doi: 10.1038/256644a0.
9
Dynamics of immunoglobulin genes.
Immunol Rev. 1977;36:73-94. doi: 10.1111/j.1600-065x.1977.tb00383.x.
10
Surface markers and functional relationships of cells involved in murine B-lymphocyte differentiation.参与小鼠B淋巴细胞分化的细胞的表面标志物及功能关系
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:33-45. doi: 10.1101/sqb.1977.041.01.007.