生长抑素抑制大鼠下丘脑器官培养物中促甲状腺素释放因子的释放。
Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus.
作者信息
Hirooka Y, Hollander C S, Suzuki S, Ferdinand P, Juan S I
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4509-13. doi: 10.1073/pnas.75.9.4509.
Abstract
Somatostatin in concentrations of 10(-6) to 10(-8) M inhibited basal release of thyrotropin releasing factor in organ culture of rat hypothalamus. Norepinephrine in doses of 10(-4)--10(-6) M induced release of thyrotropin releasing factor which increased progressively with time and was temperature and dose dependent. This enhanced thyrotropin-releasing-factor release was inhibited by somatostatin at 10(-6)--10(-8) M.
摘要
浓度为10⁻⁶至10⁻⁸M的生长抑素抑制大鼠下丘脑器官培养物中促甲状腺激素释放因子的基础释放。剂量为10⁻⁴ - 10⁻⁶M的去甲肾上腺素诱导促甲状腺激素释放因子的释放，其随时间逐渐增加，且具有温度和剂量依赖性。这种促甲状腺激素释放因子释放的增强被10⁻⁶ - 10⁻⁸M的生长抑素抑制。
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