Low W I, Ikram H
Br Heart J. 1976 Dec;38(12):1339-42. doi: 10.1136/hrt.38.12.1339.
Zinc is a metal component of many important enzymes, and its availability controls the rate of synthesis of nucleic acids and protein. Serum zinc levels have been shown to fall after acute tissue injury, including myocardial infarction. The purpose of this clinical study was to examine the value of plasma zinc measurements in a coronary care unit. Studies were made in 188 patients: 88 with unequivocal myocardial infarction, 52 controls, and 48 in a borderline group. Patients with myocardial infarction showed a fall in plasma zinc within the first three days, whereas patients in the other two groups did not. The difference in the mean minimum zinc levels between the groups with and without infarction was highly significant. In patients with myocardial infarction there was good correlation between the minimum plasma zinc level and the peal value of plasma enzymes, and also with some clinical estimators of prognosis. A fall in plasma zinc is a reliable diagnostic test for acute myocardial infarction, and the extent of the fall has prognostic implications.
锌是许多重要酶的金属成分，其可利用性控制核酸和蛋白质的合成速率。急性组织损伤（包括心肌梗死）后血清锌水平会下降。这项临床研究的目的是检验在冠心病监护病房测量血浆锌的价值。对188名患者进行了研究：88例明确诊断为心肌梗死，52例为对照组，48例为临界组。心肌梗死患者在头三天内血浆锌水平下降，而其他两组患者则未出现这种情况。梗死组与非梗死组的平均最低锌水平差异非常显著。在心肌梗死患者中，血浆最低锌水平与血浆酶峰值之间存在良好的相关性，也与一些预后的临床评估指标相关。血浆锌水平下降是急性心肌梗死的一项可靠诊断试验，下降程度具有预后意义。
