Baumanis E A, Kalnina I E, Brusovanik V I, Iablonovskaia L Ia
Arkh Patol. 1976;38(6):45-51.
To evaluate the possible antitumour effect of intensified deposition of serotonin in the region of localization of the tumour caused by a pharmacological preparation studies of the effect of inhibitors of monoamine oxidase transamine and N2N2-dibenzylhydrazide of DL-malic acid on rat's cerebellum tumour de-differentiated by astrocytoma (strain No 101/12) were carried out. The effect of inhibitors of monoamine oxidase was compared with that of antiblastic preparation of phthorafur. Differences in the mechanisms of action of pharmacological agents referred to above are shown. It was established that inhibitors of monoamine oxidase administered against the background of the developing tumour caused a considerable reduction in its weight and prononced dystrophic and necrotic changes.
为评估通过药物制剂强化5-羟色胺在肿瘤定位区域的沉积可能产生的抗肿瘤作用，开展了单胺氧化酶抑制剂、转胺以及DL-苹果酸的N2N2-二苄基酰肼对大鼠小脑经星形细胞瘤去分化的肿瘤（101/12号菌株）影响的研究。将单胺氧化酶抑制剂的作用与呋喃氟脲嘧啶抗肿瘤制剂的作用进行了比较。展示了上述药物作用机制的差异。已确定在肿瘤发展背景下给予单胺氧化酶抑制剂可使其重量显著减轻，并出现明显的营养不良和坏死变化。
