Harrigan G G, Luesch H, Yoshida W Y, Moore R E, Nagle D G, Biggs J, Park P U, Paul V J
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
J Nat Prod. 1999 Mar;62(3):464-7. doi: 10.1021/np980460u.
Five new metabolites have been isolated from a lyngbyastatin 1- and dolastatin 12-producing assemblage of Lyngbya majuscula and Schizothrix calcicola collected at Tumon Bay, Guam. Structure elucidation employed 2D NMR techniques and chemical derivatization. These compounds have been assigned the trivial names tumonoic acids A (2), B (1), and C (5); methyl tumonoate A (3), and methyl tumonoate B (4). Compounds 1 and 4 were also found in a lyngbyastatin 1-producing strain of L. majuscula from Guam.
从关岛杜梦湾采集的巨大鞘丝藻和钙裂须藻中分离出了5种新的代谢产物，它们能产生林格比他汀1和多拉司他汀12。结构解析采用了二维核磁共振技术和化学衍生化方法。这些化合物被赋予了俗名：图莫诺酸A（2）、B（1）和C（5）；图莫诺酸A甲酯（3）和图莫诺酸B甲酯（4）。在关岛产林格比他汀1的巨大鞘丝藻菌株中也发现了化合物1和4。
