Robinson T M, Kruse-Elliott K T, Markel M D, Pluhar G E, Massa K, Bjorling D E
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706-1102, USA.
J Am Anim Hosp Assoc. 1999 Mar-Apr;35(2):95-100. doi: 10.5326/15473317-35-2-95.
Postoperative analgesia provided by transdermal fentanyl was compared with that provided by epidural morphine in dogs undergoing major orthopedic surgery. Dogs randomly were assigned to receive either a 100 microg per hour transdermal fentanyl patch 24 hours prior to surgery (n=8) or epidural morphine (0.1 mg/kg body weight) administered following induction of anesthesia (n=10). Temperature, heart rate, respiratory rate, and pain score were recorded prior to surgery and zero, six, 18, 30, and 42 hours after surgery. Blood samples were collected from the dogs in the transdermal fentanyl group beginning 24 hours preoperatively to 42 hours postoperatively. Fentanyl concentrations were determined by radioimmunoassay. When all time periods after surgery were combined, dogs in the transdermal fentanyl group were experiencing significantly less pain after surgery than dogs given epidural morphine. The transdermal fentanyl provided analgesia after major orthopedic surgery greater than or equivalent to that of epidural morphine.
在接受大型骨科手术的犬类中，比较了透皮芬太尼与硬膜外吗啡提供的术后镇痛效果。犬类被随机分配，在手术前24小时接受每小时100微克的透皮芬太尼贴片（n = 8），或在麻醉诱导后给予硬膜外吗啡（0.1毫克/千克体重）（n = 10）。在手术前以及手术后0、6、18、30和42小时记录体温、心率、呼吸频率和疼痛评分。从透皮芬太尼组的犬类术前24小时开始至术后42小时采集血样。通过放射免疫测定法测定芬太尼浓度。当合并手术后的所有时间段时，透皮芬太尼组的犬类术后疼痛明显低于给予硬膜外吗啡的犬类。透皮芬太尼在大型骨科手术后提供的镇痛效果大于或等同于硬膜外吗啡。
