阿仑膦酸盐在种植体周围缺损再生中的应用。

Use of alendronate in peri-implant defect regeneration.

作者信息

Meraw S J, Reeve C M, Wollan P C

机构信息

Department of Dental Specialties, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

出版信息

J Periodontol. 1999 Feb;70(2):151-8. doi: 10.1902/jop.1999.70.2.151.

DOI:10.1902/jop.1999.70.2.151

PMID:10102552

Abstract

BACKGROUND

Previous studies have demonstrated an increase in bone mass and density with use of systemic alendronate sodium. This agent acts as an inhibitor of osteoclast activity, and is thought to result in more net osteoblastic activity. The objective of this study was to determine the effects of locally applied alendronate sodium on guided bone regeneration around dental implants.

METHODS

Six adult mongrel dogs were divided into 2 groups: one group received alendronate-coated dental implants, and the other group served as control. Two types of dental implants were used in each dog: hydroxyapatite (HA)-coated and titanium machine-polished (TMP), for a total of 4 groups. Dental implants were placed immediately after extraction of the right and left second, third, and fourth mandibular premolars; a resorbable collagen membrane was secured over the implants and defects; and the flaps were closed primarily. Fluorescent labels were administered intravenously on days 0, 6, 12, and 22 to measure bone formation rate. Dogs were sacrificed on day 28. The specimens were sectioned and mounted, and bone formation rate was recorded with a computerized microscopic digitizer. Specimens were stained with Stevenel's blue and van Gieson's picric fuchsin. Bone-to-implant contact was recorded with a computerized microscopic digitizer.

RESULTS

The results indicated a significant effect of locally applied alendronate (P < 0.0001) with both types of implants (HA and TMP), as well as the HA coating (P< 0.02) on increased bone formation rate. Additionally, alendronate had a significant effect on bone-to-implant contact, with an increase in the TMP model (P < 0.0001) and a decrease in the HA model (P < 0.0001 ). HA coating also had a significant effect on increasing bone-to-implant contact (P < 0.04).

CONCLUSIONS

The results indicate that alendronate increases early bone formation rate around dental implants. Additionally, the local application as described resulted in greater bone-to-implant contact with TMP implants.

摘要

背景

先前的研究表明，使用全身性阿仑膦酸钠可增加骨量和骨密度。该药物作为破骨细胞活性抑制剂，被认为可导致更多的净成骨细胞活性。本研究的目的是确定局部应用阿仑膦酸钠对牙种植体周围引导性骨再生的影响。

方法

将6只成年杂种犬分为2组：一组接受阿仑膦酸涂层牙种植体，另一组作为对照组。每只犬使用两种类型的牙种植体：羟基磷灰石（HA）涂层和钛机械抛光（TMP），共4组。在拔除左右下颌第二、第三和第四前磨牙后立即植入牙种植体；在种植体和骨缺损上方固定可吸收胶原膜；然后一期缝合创口。在第0、6、12和22天静脉注射荧光标记物以测量骨形成率。在第28天处死犬。将标本切片并固定，用计算机显微镜数字化仪记录骨形成率。标本用史蒂文斯蓝和范吉森苦味品红染色。用计算机显微镜数字化仪记录骨与种植体的接触情况。

结果

结果表明，局部应用阿仑膦酸钠对两种类型的种植体（HA和TMP）以及HA涂层均有显著影响（P < 0.0001），可提高骨形成率。此外，阿仑膦酸钠对骨与种植体的接触有显著影响，在TMP模型中增加（P < 0.0001），在HA模型中减少（P < 0.0001）。HA涂层对增加骨与种植体的接触也有显著影响（P < 0.04）。