Radboudumc, Department of Regenerative Biomaterials, Nijmegen, The Netherlands.
Radboudumc, Department of Plastic, Reconstructive and Hand Surgery, Nijmegen, The Netherlands.
Sci Rep. 2018 Oct 18;8(1):15398. doi: 10.1038/s41598-018-33692-5.
Osteoporosis represents a major health problem in terms of compromising bone strength and increasing the risk of bone fractures. It can be medically treated with bisphosphonates, which act systemically upon oral or venous administration. Further, bone regenerative treatments in osteoporotic conditions present a challenge. Here, we focused on the development of a synthetic bone substitute material with local diminishing effects on osteoporosis. Composites were created using calcium phosphate cement (CPC; 60 wt%) and polylactic-co-glycolic acid (PLGA; 40 wt%), which were loaded with alendronate (ALN). In vitro results showed that ALN-loaded CPC/PLGA composites presented clinically suitable properties, including setting times, appropriate compressive strength, and controlled release of ALN, the latter being dependent on composite degradation. Using a rat femoral condyle bone defect model in osteoporotic animals, ALN-loaded CPC/PLGA composites demonstrated stimulatory effects on bone formation both within and outside the defect region.
骨质疏松症是一个主要的健康问题，会影响骨骼强度并增加骨折风险。可以通过双膦酸盐进行医学治疗，双膦酸盐通过口服或静脉给药发挥全身作用。此外，骨质疏松症的骨再生治疗也存在挑战。在这里，我们专注于开发一种具有局部缓解骨质疏松作用的合成骨替代材料。复合材料由磷酸钙水泥（CPC；60wt%）和聚乳酸-羟基乙酸共聚物（PLGA；40wt%）制成，并负载阿仑膦酸钠（ALN）。体外结果表明，载有 ALN 的 CPC/PLGA 复合材料具有临床适用的特性，包括凝固时间、适当的抗压强度和 ALN 的控制释放，后者取决于复合材料的降解。在骨质疏松动物的大鼠股骨髁骨缺损模型中，载有 ALN 的 CPC/PLGA 复合材料在缺损区域内外均表现出对骨形成的刺激作用。
