Weng G, Bhalla U S, Iyengar R
Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Science. 1999 Apr 2;284(5411):92-6. doi: 10.1126/science.284.5411.92.
Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.
生物信号通路相互作用形成复杂的网络。复杂性源于大量的组成部分，其中许多具有功能部分重叠的异构体；源于组成部分之间的连接；以及源于组成部分之间的空间关系。本文讨论了信号网络复杂行为的起源以及应对这种新出现的复杂性的分析方法。
