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在水杨酸盐存在的情况下生长会增加金黄色葡萄球菌对氟喹诺酮类药物的耐药性。

Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus.

作者信息

Gustafson J E, Candelaria P V, Fisher S A, Goodridge J P, Lichocik T M, McWilliams T M, Price C T, O'Brien F G, Grubb W B

机构信息

Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Western Australia, Australia.

出版信息

Antimicrob Agents Chemother. 1999 Apr;43(4):990-2. doi: 10.1128/AAC.43.4.990.

DOI:10.1128/AAC.43.4.990
PMID:10103221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89247/
Abstract

Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.

摘要

水杨酸盐和乙酰水杨酸盐会使对环丙沙星敏感及耐药的金黄色葡萄球菌的氟喹诺酮耐药性略有增加。水杨酸盐能使更多来自对环丙沙星敏感及耐药菌株的细胞在高浓度氟喹诺酮环境下存活。水杨酸盐还提高了敏感菌株突变为对环丙沙星耐药性更强的菌株的频率。

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