重症监护病房中耐环丙沙星和耐甲氧西林金黄色葡萄球菌流行菌株在定植患者中的分子特征分析
Molecular characterization of epidemic ciprofloxacin- and methicillin-resistant Staphylococcus aureus strains colonizing patients in an intensive care unit.
作者信息
Udo E E, al-Obaid I A, Jacob L E, Chugh T D
机构信息
Department of Microbiology, Faculty of Medicine, Kuwait University.
出版信息
J Clin Microbiol. 1996 Dec;34(12):3242-4. doi: 10.1128/jcm.34.12.3242-3244.1996.
Abstract
Eighteen methicillin-resistant Staphylococcus aureus (MRSA) samples isolated from patients and the environment in an intensive care unit (ICU) during a routine surveillance were tested for antimicrobial resistance and typed by pulsed-field gel electrophoresis. Three pulsed-field patterns were observed. Sixteen were ciprofloxacin resistant and had identical pulsed-field patterns. The results suggested that a ciprofloxacin-resistant MRSA clone had contaminated the environment and spread among patients. This study demonstrates the application of infection control surveillance combined with strain typing in detecting MRSA colonization in the ICU where it was not known to exist.
摘要
在一次常规监测中，从重症监护病房（ICU）的患者和环境中分离出18株耐甲氧西林金黄色葡萄球菌（MRSA）样本，检测其抗菌耐药性，并通过脉冲场凝胶电泳进行分型。观察到三种脉冲场图谱。16株对环丙沙星耐药且具有相同的脉冲场图谱。结果表明，一株耐环丙沙星的MRSA克隆株污染了环境并在患者中传播。本研究证明了感染控制监测与菌株分型相结合在检测ICU中未知存在的MRSA定植方面的应用。
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