Sakai T, Fujishima I, Sugiyama K, Ryu H, Uemura K
Seirei Mikatabara General Hospital, Hamamatsu, Japan.
J Clin Laser Med Surg. 1992 Feb;10(1):37-40. doi: 10.1089/clm.1992.10.37.
Deep-seated brain tumor is difficult to treat surgically. Hyperthermia using various energy sources has been tried, but has failed to gain wide use because of equipment problems and poor temperature control. It is possible now to use Nd:YAG laser with a stable low-energy supply as an energy source for laser hyperthermia (laserthermia). Animal study and clinical study were done using SLT CL50, Computer-control Laserthermia System to treat deep-seated brain tumors. Experimental study revealed that laserthermia produced minimal edema, temperature control was satisfactory, and blood-brain barrier opened up for 6 days following laserthermia. Five patients with brain tumors were treated with laserthermia. Follow-up CT scan revealed disappearance of tumor in 4 patients and decrease in volume in 1 patient. Long-term neurological follow up revealed no deterioration. Laserthermia using Nd:YAG laser is safe and easy to use and it is beneficial to treat deep-seated brain tumors.
深部脑肿瘤手术治疗困难。人们尝试过使用各种能源进行热疗，但由于设备问题和温度控制不佳，未能得到广泛应用。现在可以使用具有稳定低能量供应的Nd:YAG激光作为激光热疗（激光热凝术）的能源。使用SLT CL50计算机控制激光热凝系统对深部脑肿瘤进行了动物研究和临床研究。实验研究表明，激光热疗产生的水肿最小，温度控制良好，激光热疗后血脑屏障开放6天。5例脑肿瘤患者接受了激光热疗。随访CT扫描显示4例患者肿瘤消失，1例患者肿瘤体积减小。长期神经学随访显示无病情恶化。使用Nd:YAG激光进行激光热疗安全且易于操作，对治疗深部脑肿瘤有益。
