DiCarlo E F, Bullough P G
Cornell University Medical College, Department of Laboratory Medicine, New York 10021.
Clin Mater. 1992;9(3-4):235-60. doi: 10.1016/0267-6605(92)90104-2.
The use of artificial materials in the treatment of orthopaedic conditions, most notably arthritis, over the past few decades has been increasing dramatically. Such use makes an understanding of the tissue responses to the various materials necessary to determine their effectiveness and acceptability. This review concentrates on the studies of the biological responses to the materials that are used mainly in joint replacements and fixation of fractures. In-vivo and in-vitro experimental studies of various metals, polymers and ceramics and their constituents are first presented with discussions regarding their clinical importance. Studies of clinically successful implants are then presented to illustrate the expected morphological features of incorporation and acceptance by the host tissues. The local and systemic effects complicating the use of the implanted materials as well as the failure of the implant are then presented.
在过去几十年中，人工材料在骨科疾病治疗中的应用，尤其是在关节炎治疗中的应用，一直在急剧增加。这种应用使得了解组织对各种材料的反应对于确定其有效性和可接受性变得必要。本综述主要关注对主要用于关节置换和骨折固定的材料的生物学反应的研究。首先介绍了各种金属、聚合物和陶瓷及其成分的体内和体外实验研究，并讨论了它们的临床重要性。然后介绍了临床成功植入物的研究，以说明宿主组织融合和接受的预期形态特征。接着介绍了植入材料使用过程中出现的局部和全身影响以及植入物的失败情况。
