Marks J L, Pomerleau C S, Pomerleau O F
University of Michigan, Department of Psychiatry, Ann Arbor 48108, USA.
Addict Behav. 1999 Jan-Feb;24(1):127-34. doi: 10.1016/s0306-4603(98)00033-1.
The possible impact of menstrual phase upon reactivity to nicotine was investigated in 12 healthy women smokers. Controlled doses of nicotine were administered via an intranasal aerosol delivery device to overnight-deprived women smokers in four hormonally verified menstrual phases. Physiological, biochemical, and subjective measures were collected. Cycle-related symptomatology differed significantly across phase, with lowest values during the mid-follicular phase. No significant differences were found for baseline variables, including withdrawal measures. Nicotine increment was stable across phase, confirming reliability of the dosing method. No significant menstrual phase differences were found for physiological, subjective, or biochemical responses to nicotine. Pending investigations conducted over longer intervals, in a wider variety of subjects; findings suggest that for this type of study, complex strategies to control for menstrual-cycle phase effects may be unnecessary.
在12名健康女性吸烟者中研究了月经周期对尼古丁反应性的可能影响。通过鼻内气雾剂给药装置，向处于四个经激素验证的月经周期阶段、通宵未吸烟的女性吸烟者给予可控剂量的尼古丁。收集了生理、生化和主观指标。不同阶段的周期相关症状有显著差异，在卵泡中期症状值最低。包括戒断指标在内的基线变量未发现显著差异。各阶段尼古丁增量稳定，证实了给药方法的可靠性。对尼古丁的生理、主观或生化反应在月经周期各阶段未发现显著差异。在更长时间间隔内、对更多样化的受试者进行的待研究表明，对于这类研究，控制月经周期阶段效应的复杂策略可能没有必要。
