近期接种麻疹疫苗不会干扰对黄热病疫苗的血清反应。
Recent immunization against measles does not interfere with the sero-response to yellow fever vaccine.
作者信息
Stefano I, Sato H K, Pannuti C S, Omoto T M, Mann G, Freire M S, Yamamura A M, Vasconcelos P F, Oselka G W, Weckx L W, Salgado M F, Noale L F, Souza V A
机构信息
Centro de Vigilância Epidemiológica Prof. Alexandre Vranjac, Secretaria de Estado da Saúde de São Paulo, SP, Brazil.
出版信息
Vaccine. 1999 Mar 5;17(9-10):1042-6. doi: 10.1016/s0264-410x(98)00320-x.
In order to determine whether previous measles vaccination interferes with the sero-response to yellow fever vaccine, 294 children at nine months of age were randomly assigned to immunization with yellow fever vaccine at different time intervals after measles vaccination. The seroconversion rate (SCR) and the log10 geometric mean titer (GMT) for 17 DD yellow fever vaccine at different intervals after Schwarz measles vaccination were: 1-6 days: SCR = 44/57 = 77%; GMT = 4.57; 7-13 days: SCR = 36/53 = 68%; GMT = 4.46; 14-21 days: SCR = 55/65 = 85%; GMT = 4.46; 22-27 days: SCR = 41/54 = 76%; GMT = 4.41 and >28 days: SCR = 52/65 = 80%; GMT = 4.24 (p > 0.05). We conclude that recent immunization against measles does not interfere with the sero-response to yellow fever vaccine.
为了确定既往麻疹疫苗接种是否会干扰对黄热病疫苗的血清反应，294名9月龄儿童在接种麻疹疫苗后的不同时间间隔被随机分配接受黄热病疫苗免疫。在施瓦茨麻疹疫苗接种后的不同间隔，17D黄热病疫苗的血清转化率（SCR）和log10几何平均滴度（GMT）分别为：1 - 6天：SCR = 44/57 = 77%；GMT = 4.57；7 - 13天：SCR = 36/53 = 68%；GMT = 4.46；14 - 21天：SCR = 55/65 = 85%；GMT = 4.46；22 - 27天：SCR = 41/54 = 76%；GMT = 4.41；>28天：SCR = 52/65 = 80%；GMT = 4.24（p>0.05）。我们得出结论，近期接种麻疹疫苗不会干扰对黄热病疫苗的血清反应。
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