Marianneau P, Steffan A M, Royer C, Drouet M T, Jaeck D, Kirn A, Deubel V
Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, France.
J Virol. 1999 Jun;73(6):5201-6. doi: 10.1128/JVI.73.6.5201-5206.1999.
We investigated the ability of dengue virus to invade human primary Kupffer cells and to complete its life cycle. The virus effectively penetrated Kupffer cells, but the infection did not result in any viral progeny. Dengue virus-replicating Kupffer cells underwent apoptosis and were cleared by phagocytosis. Infected Kupffer cells produced soluble mediators that could intervene in dengue virus pathogenesis.