用体外培养的恶性疟原虫抗原进行疟疾免疫接种。
Immunization against malaria with antigen from Plasmodium falciparum cultivated in vitro.
作者信息
Reese R T, Trager W, Jensen J B, Miller D A, Tantravahi R
出版信息
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5665-8. doi: 10.1073/pnas.75.11.5665.
Abstract
Aotus monkeys, which are generally killed when infected with the human malaria parasite Plasmodium falciparum, have been identified and grouped by karyotype. These animals were immunized with parasite material obtained from P. falciparum cultivated in vitro which had been maintained in culture for over a year. When sufficient amounts of this antigenic material were used with a synthetic muramyl dipeptide (MDP), protective immunity was induced without presenting the antigen in complete Freund's adjuvant.
摘要
通常感染人类疟原虫恶性疟原虫后会死亡的夜猴，已通过核型进行了鉴定和分类。这些动物用从体外培养超过一年的恶性疟原虫获得的寄生虫材料进行免疫。当使用足够量的这种抗原性材料与合成的胞壁酰二肽（MDP）一起使用时，无需在完全弗氏佐剂中呈递抗原就能诱导出保护性免疫。
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