用体外培养的恶性疟原虫抗原进行疟疾免疫接种。
Immunization against malaria with antigen from Plasmodium falciparum cultivated in vitro.
作者信息
Reese R T, Trager W, Jensen J B, Miller D A, Tantravahi R
出版信息
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5665-8. doi: 10.1073/pnas.75.11.5665.
Abstract
Aotus monkeys, which are generally killed when infected with the human malaria parasite Plasmodium falciparum, have been identified and grouped by karyotype. These animals were immunized with parasite material obtained from P. falciparum cultivated in vitro which had been maintained in culture for over a year. When sufficient amounts of this antigenic material were used with a synthetic muramyl dipeptide (MDP), protective immunity was induced without presenting the antigen in complete Freund's adjuvant.
摘要
通常感染人类疟原虫恶性疟原虫后会死亡的夜猴，已通过核型进行了鉴定和分类。这些动物用从体外培养超过一年的恶性疟原虫获得的寄生虫材料进行免疫。当使用足够量的这种抗原性材料与合成的胞壁酰二肽（MDP）一起使用时，无需在完全弗氏佐剂中呈递抗原就能诱导出保护性免疫。
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本文引用的文献
1
IMMUNIZATION OF RHESUS MONKEYS AGAINST MALARIAL INFECTION (P. KNOWLESI) WITH KILLED PARASITES AND ADJUVANTS.用灭活寄生虫和佐剂对恒河猴进行抗疟原虫（诺氏疟原虫）感染的免疫接种。
Science. 1945 Aug 24;102(2643):202-4. doi: 10.1126/science.102.2643.202.
2
IMMUNIZATION AGAINST MALARIA: VACCINATION OF DUCKS WITH KILLED PARASITES INCORPORATED WITH ADJUVANTS.疟疾免疫：用佐剂包裹的死寄生虫对鸭子进行疫苗接种。
Science. 1945 Aug 24;102(2643):200-2. doi: 10.1126/science.102.2643.200.
3
Backcross Studies on the Genetics of Resistance to Malaria in Mice.小鼠对疟疾抗性遗传学的回交研究。
Genetics. 1955 Sep;40(5):620-6. doi: 10.1093/genetics/40.5.620.
4
The enhanced folic and folinic acid contents of erythrocytes infected with malaria parasites.感染疟原虫的红细胞中叶酸和亚叶酸含量增加。
Exp Parasitol. 1959 Jun;8(3):265-73. doi: 10.1016/0014-4894(59)90025-6.
5
6
Some characteristics of Plasmodium berghei passed within inbred strains of mice.
J Parasitol. 1957 Aug;43(4):420-7.
7
Parasitemia and survival in inbred strains of mice infected with Plasmodium berghei.
J Parasitol. 1957 Aug;43(4):413-9.
8
Resistance produced in owl monkeys (Aotus trivirgatus) by inoculation with irradiated Plasmodium falciparum.
Mil Med. 1969 Sep;134(10):1165-75.
9
Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi.疟疾免疫：诺氏疟原虫慢性感染中的抗原变异
Nature. 1965 Dec 25;208(5017):1286-8. doi: 10.1038/2081286a0.
10
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.细菌肽聚糖衍生物佐剂活性的最小结构要求。
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25. doi: 10.1016/0006-291x(74)90458-6.
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