Bauwens M, De Coninck A, Roseeuw D
Department of Dermatology, Vrije Universiteit Brussel, Belgium.
Dermatology. 1999;198(2):203-5. doi: 10.1159/000018113.
Subcorneal pustular dermatosis (SPD) is a chronic recurrent pustular dermatosis of unknown etiology. Many treatments have been proposed, none of which has been uniformly successful.
Our purpose is to report a patient with SPD successfully treated by PUVA and to review the literature concerning phototherapy treatment of SPD.
A patient suffering from SPD resistant to diaminodiphenylsulphone (dapsone) responded well to a combination therapy consisting of dapsone and PUVA. He received 50 mg/day and 3 PUVA sessions a week. Photographs were taken at baseline and after 15 sessions.
The lesions were virtually cleared after 15 sessions. The patient remained free of lesions with a maintenance therapy of dapsone (50 mg/ day) and 1 PUVA session a week.
The therapeutic value of phototherapy for the treatment of SPD still has to be confirmed and could be a valuable alternative for treatment-resistant patients.
角层下脓疱性皮肤病（SPD）是一种病因不明的慢性复发性脓疱性皮肤病。已经提出了许多治疗方法，但没有一种是一直有效的。
我们的目的是报告一例用补骨脂素加紫外线A（PUVA）成功治疗的SPD患者，并复习有关SPD光疗的文献。
一名对二氨基二苯砜（氨苯砜）耐药的SPD患者对氨苯砜和PUVA联合治疗反应良好。他每天服用50毫克氨苯砜，每周接受3次PUVA治疗。在基线和15次治疗后拍摄照片。
15次治疗后皮损基本消退。患者通过氨苯砜（50毫克/天）维持治疗和每周1次PUVA治疗，皮损持续未复发。
光疗对SPD的治疗价值仍有待证实，对于难治性患者可能是一种有价值的替代治疗方法。
