Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Drug Deliv. 2021 Dec;28(1):752-766. doi: 10.1080/10717544.2021.1909175.
Macrophages are a major component of the immunoresponse. Diversity and plasticity are two of the hallmarks of macrophages, which allow them to act as proinflammatory, anti-inflammatory, and homeostatic agents. Research has found that cancer and many inflammatory or autoimmune disorders are correlated with activation and tissue infiltration of macrophages. Recent developments in macrophage nanomedicine-based disease treatment are proving to be timely owing to the increasing inadequacy of traditional treatment. Here, we review the role of macrophages in nanomedicine-based disease treatment. First, we present a brief background on macrophages and nanomedicine. Then, we delve into applications of macrophages as a target for disease treatment and delivery systems and summarize the applications of macrophage-derived extracellular vesicles. Finally, we provide an outlook on the clinical utility of macrophages in nanomedicine-based disease treatment.
巨噬细胞是免疫反应的主要组成部分。多样性和可塑性是巨噬细胞的两个特征，使它们能够作为促炎、抗炎和稳态调节剂发挥作用。研究发现，癌症和许多炎症或自身免疫性疾病与巨噬细胞的激活和组织浸润有关。由于传统治疗方法的不足日益加剧，基于巨噬细胞的纳米医学疾病治疗的最新进展被证明是及时的。在这里，我们综述了巨噬细胞在基于纳米医学的疾病治疗中的作用。首先，我们简要介绍了巨噬细胞和纳米医学的背景。然后，我们深入探讨了巨噬细胞作为疾病治疗和递药系统靶点的应用，并总结了巨噬细胞衍生的细胞外囊泡的应用。最后，我们对巨噬细胞在基于纳米医学的疾病治疗中的临床应用进行了展望。
