性甾体激素的免疫抑制作用。对PHA和PPD刺激淋巴细胞的影响。
Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.
作者信息
Wyle F A, Kent J R
出版信息
Clin Exp Immunol. 1977 Mar;27(3):407-15.
Abstract
Progesterone, estradiol, testosterone, cortisol, and 11-desoxycortisol (compound S) were added to cultures of human lymphocytes stimulated with phytohaemagglutinin (PHA) and purified protein derivative (PPD). The immunosuppressive effect of cortisol was verified and the three sex-steroid hormones also were found to inhibit lymphocyte transformation although at concentrations higher than for cortisol. Compound S, a steroid of low biological potency, also had immunosuppressive activity. At concentrations (0-01-1-0 microng/ml), progesterone, oestrogen, testosterone, and Compound S augmented the transformation response to PPD but not to PHA. Marked variation from individual to individual in the suppressive effects of all the steroids were noted. The clinical implications of immunosuppression by the sex steroid hormones are discussed.
摘要
将孕酮、雌二醇、睾酮、皮质醇和11-脱氧皮质醇（化合物S）添加到用植物血凝素（PHA）和纯化蛋白衍生物（PPD）刺激的人淋巴细胞培养物中。皮质醇的免疫抑制作用得到了证实，并且还发现三种性激素也能抑制淋巴细胞转化，尽管其浓度高于皮质醇。化合物S是一种生物活性较低的类固醇，也具有免疫抑制活性。在浓度为0.01 - 1.0微克/毫升时，孕酮、雌激素、睾酮和化合物S增强了对PPD而非PHA的转化反应。注意到所有类固醇的抑制作用在个体之间存在显著差异。讨论了性激素免疫抑制的临床意义。
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