Brown V J, Robbins T W
Department of Experimental Psychology, University of Cambridge, United Kingdom.
J Neurosci. 1989 Nov;9(11):3760-5. doi: 10.1523/JNEUROSCI.09-11-03760.1989.
The relative contributions of the medial and lateral caudate putamen to performance of a visual reaction time task were compared by examining the effects of unilateral ibotenate-induced lesions to these regions in the rat. Different groups of rats were trained to respond either towards (Discrimination 1) or away from (Discrimination 2) unpredictable, brief visual stimuli presented to either side of the head. Lateral striatal lesions produced a strong spatial bias towards the side of the lesion but left the latency for the initiation of responses to the visual cues unchanged. By contrast, the medial striatal lesions resulted in a smaller degree of spatial response bias but a significant slowing of initiation latency to the side contralateral to the lesion. These effects were irrespective of the side of the stimulus presentation and thus represent response-related impairments. The lesions were further dissociated in their effects on responding inappropriately to task requirements. These results demonstrate a double dissociation of behavioral effects of lateral and medial striatal damage that can be used to infer the operation of distinct elementary processes of response output within a single task. They are important not only in demonstrating functional effects of hypothetical segregated parallel corticostriatal loops but also in showing that these loops must interact to produce integrated performance.
通过检查单侧鹅膏蕈氨酸诱导的大鼠这些区域损伤的影响，比较了内侧和外侧尾状壳核在视觉反应时间任务表现中的相对贡献。不同组的大鼠被训练对呈现于头部任一侧的不可预测的短暂视觉刺激做出朝向（辨别1）或远离（辨别2）的反应。外侧纹状体损伤产生了强烈的朝向损伤侧的空间偏差，但对视觉线索开始反应的潜伏期没有影响。相比之下，内侧纹状体损伤导致空间反应偏差程度较小，但损伤对侧的反应起始潜伏期显著延长。这些效应与刺激呈现的一侧无关，因此代表了与反应相关的损伤。这些损伤在对不符合任务要求的反应的影响上进一步分离。这些结果证明了外侧和内侧纹状体损伤行为效应的双重分离，可用于推断单一任务中不同基本反应输出过程的运作。它们不仅在证明假设的分离平行皮质纹状体环路的功能效应方面很重要，而且在表明这些环路必须相互作用以产生整合表现方面也很重要。
