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[二氯乙烷中毒大鼠肝脏和心肌中烟酰胺辅酶的水平]

[Level of nicotinamide coenzymes in the liver and myocardium of rats poisoned with dichlorethane].

作者信息

Natsiuk M V, Chekman I S

出版信息

Biull Eksp Biol Med. 1975 Apr;79(4):58-60.

PMID:104
Abstract

Experiments were conducted on male rats. A study was made of the content of nicotinamide coenzymes in the liver and myocardium 24 hours after the administration of 0.5 ml of dichloroethane into the stomach. In parallel with disturbance of the morphological structure of the liver and of the myocardium, increase in the activity of alanine and aspargic aminotranspherases in the blood serum, dichloroethane reduced the content of nicotinamide coenzymes and deranged the ratio of their oxidized and reduced forms in these organs.

摘要

对雄性大鼠进行了实验。研究了给大鼠胃内注入0.5毫升二氯乙烷24小时后肝脏和心肌中烟酰胺辅酶的含量。除了肝脏和心肌的形态结构受到干扰、血清中丙氨酸和天冬氨酸转氨酶活性增加外,二氯乙烷还降低了这些器官中烟酰胺辅酶的含量,并扰乱了其氧化型和还原型的比例。

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