Kraemer R R, Johnson L G, Haltom R, Kraemer G R, Hebert E P, Gimpel T, Castracane V D
Department of Kinesiology and Health Studies, Southeastern Louisiana University, Hammond, Louisiana 70402, USA.
Proc Soc Exp Biol Med. 1999 Jul;221(3):171-7. doi: 10.1046/j.1525-1373.1999.d01-72.x.
The purpose of the study was to examine the effects of acute exercise and hormone replacement therapy on serum leptin concentrations in postmenopausal women. Subjects were 15 healthy, postmenopausal women, 8 on hormone replacement therapy (HRT) and 7 not on hormone replacement therapy (NHRT). Group comparisons indicated no significant differences between HRT and NHRT groups with respect to age, height, weight, BMI, sum of skinfolds, or VO2max, and verified significant differences in estradiol and FSH concentrations. After an overnight fast, each subject completed 30 min of treadmill exercise at approximately 80% VO2max. Over 2 hr and 10 min, baseline, exercise, and recovery blood samples were collected from an intravenous catheter. A control session conducted a month later consisted of the same blood sampling protocol without exercise. Leptin concentrations declined significantly over the course of both the exercise and control sessions, gradually decreasing from baseline levels to -1.54 +/- 0.49 ng. ml-1 postexercise, and continuing to decline to a low of -2.89 +/- 0.59 ng. ml-1 at the end of the session. There was no significant difference between groups with respect to this decline. This is the first study to document that diurnal changes in leptin concentrations in postmenopausal women are not altered by acute treadmill exercise or HRT status. The study underscores the need to account for a diurnal reduction in leptin over the course of an exercise trial.
该研究的目的是探讨急性运动和激素替代疗法对绝经后妇女血清瘦素浓度的影响。研究对象为15名健康的绝经后妇女，其中8名接受激素替代疗法（HRT），7名未接受激素替代疗法（NHRT）。组间比较显示，HRT组和NHRT组在年龄、身高、体重、BMI、皮褶厚度总和或最大摄氧量方面无显著差异，并证实了雌二醇和促卵泡激素浓度存在显著差异。在禁食过夜后，每位受试者在约80%最大摄氧量的强度下在跑步机上完成30分钟的运动。在2小时10分钟内，通过静脉导管采集基线、运动中和恢复阶段的血样。一个月后进行的对照实验采用相同的采血方案，但不进行运动。在运动和对照实验过程中，瘦素浓度均显著下降，从基线水平逐渐降至运动后-1.54±0.49 ng/ml，并在实验结束时继续降至-2.89±0.59 ng/ml的低点。两组在这种下降方面无显著差异。这是第一项记录绝经后妇女瘦素浓度的昼夜变化不受急性跑步机运动或HRT状态影响的研究。该研究强调了在运动试验过程中考虑瘦素昼夜减少的必要性。
