Gemma C, Opp M R
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555-0431, USA.
J Neuroimmunol. 1999 Jun 1;97(1-2):94-101. doi: 10.1016/s0165-5728(99)00052-1.
Sleep is altered during all stages at which it has been recorded during chronic human immunodeficiency virus (HIV) infection, including the long latent phase before the development of AIDS; the mechanisms for such alterations are not known. The HIV envelope glycoprotein (gp) 120 alters sleep of rats in a manner somewhat similar to the alterations that occur in humans infected with HIV. To further determine which components of the virus may be responsible for altered behavior, we administered centrally into rats prior to dark onset recombinant HIV gp160 or gp41. Both glycoproteins increased non-rapid eye movements sleep, fragmented sleep, altered slow frequency components of the electroencephalogram, and induced modest febrile responses. These results complement and extend those previously obtained after gp120; HIV envelope glycoproteins are capable of altering sleep.
在慢性人类免疫缺陷病毒（HIV）感染期间，睡眠在所有已记录的阶段都会发生改变，包括艾滋病发展之前的长期潜伏期；这种改变的机制尚不清楚。HIV包膜糖蛋白（gp）120改变大鼠睡眠的方式与感染HIV的人类所发生的改变有些相似。为了进一步确定病毒的哪些成分可能导致行为改变，我们在天黑前向大鼠脑内注射重组HIV gp160或gp41。两种糖蛋白均增加了非快速眼动睡眠、使睡眠碎片化、改变了脑电图的慢频率成分，并引起适度的发热反应。这些结果补充并扩展了先前在gp120之后获得的结果；HIV包膜糖蛋白能够改变睡眠。
