Takyi E E
Nutrition Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
J Nutr. 1999 Aug;129(8):1549-54. doi: 10.1093/jn/129.8.1549.
A randomized, double-blind, controlled study was conducted to determine whether the consumption of leafy vegetables by preschool children would enhance their serum vitamin A concentration to acceptable levels. Preschool children (n = 519; 2.5-6 y) in Saboba, northern Ghana, were randomly assigned to five feeding groups, differing essentially in the amount of fat and beta-carotene, fed once per d, 7 d per wk, for 3 mo. Serum retinol levels, anthropometric measurements, hemoglobin, rapid turnover proteins (pre-albumin and retinol-binding protein), worm infestation (stool examinations) and level of acute and chronic infection (serum C-reactive protein and acid glycoprotein) were determined before and after study. Relative to the baseline serum retinol values, consumption of dark green, leafy vegetables (Manihot sp. and Ceiba sp.) with fat (10 g/100 g) significantly (P < 0.05) enhanced serum retinol; consequently, the percentage of children with adequate retinol status increased from 28.2-48.2% after feeding (P < 0.05). There were no significant differences among groups, ages or pre- versus post-anthropometric measurements, hemoglobin concentration, or levels of worm infestation. The importance of these findings in alleviating and/or controlling vitamin A deficiency in developing countries is discussed.
开展了一项随机、双盲、对照研究，以确定学龄前儿童食用绿叶蔬菜是否会将其血清维生素A浓度提高到可接受水平。在加纳北部萨博巴的学龄前儿童（n = 519；2.5 - 6岁）被随机分配到五个喂养组，主要区别在于脂肪和β-胡萝卜素的含量，每天喂食一次，每周7天，共3个月。在研究前后测定血清视黄醇水平、人体测量指标、血红蛋白、快速周转蛋白（前白蛋白和视黄醇结合蛋白）、蠕虫感染（粪便检查）以及急性和慢性感染水平（血清C反应蛋白和酸性糖蛋白）。相对于基线血清视黄醇值，食用含脂肪（10 g/100 g）的深绿色叶菜（木薯属和吉贝属）显著（P < 0.05）提高了血清视黄醇水平；因此，喂养后视黄醇状态充足的儿童百分比从28.2%增至48.2%（P < 0.05）。各组之间、不同年龄组以及人体测量指标、血红蛋白浓度或蠕虫感染水平在研究前后均无显著差异。讨论了这些研究结果在缓解和/或控制发展中国家维生素A缺乏症方面的重要性。
