Yoshimitsu N, Douchi T, Yamasaki H, Nagata Y, Andoh T, Hatano H
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Japan.
Br J Obstet Gynaecol. 1999 Feb;106(2):144-7. doi: 10.1111/j.1471-0528.1999.tb08214.x.
To investigate whether umbilical cord serum lipid levels differ with mode of delivery.
Retrospective observation study.
Two hundred and ninety mothers aged 29.1 years (SD 4.7) who had vaginal delivery, and 44 mothers aged 30.4 years (SD 4.7) who had elective caesarean section were enrolled.
Maternal and umbilical cord blood were obtained immediately after delivery. Serum lipid levels including total cholesterol, high density lipoprotein cholesterol, saturated fatty acid, mono-unsaturated fatty acid and polyunsaturated fatty acid were measured. Obstetric variables and serum lipid levels were compared between the two groups. In each group the correlations of fetal serum lipid levels with maternal serum lipid levels were investigated.
There were no significant differences in maternal age, neonatal weight, gestational duration, placental weight and neonatal gender distribution between the two groups. Only the two fetal serum lipid levels (including total cholesterol and non-high density lipoprotein cholesterol) showed a correlation with maternal fetal lipid levels with correlation coefficients > 0.3 in the caesarean section group. However, saturated fatty acid, mono-unsaturated fatty acid and total fatty acid levels in the non-high density lipoprotein low density lipoprotein, very low density lipoprotein, intermediate density lipoprotein and free fatty acid fraction in the umbilical cord serum were significantly higher in the vaginal delivery cases (P < 0.01).
Umbilical cord serum levels of saturated and mono-unsaturated fatty acids increase during vaginal delivery.
研究脐带血脂水平是否因分娩方式而异。
回顾性观察研究。
招募了290名年龄为29.1岁（标准差4.7）经阴道分娩的母亲，以及44名年龄为30.4岁（标准差4.7）行择期剖宫产的母亲。
分娩后立即采集母血和脐带血。测量血脂水平，包括总胆固醇、高密度脂蛋白胆固醇、饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸。比较两组的产科变量和血脂水平。在每组中，研究胎儿血脂水平与母体血脂水平的相关性。
两组之间的母亲年龄、新生儿体重、孕周、胎盘重量和新生儿性别分布无显著差异。仅剖宫产组中两种胎儿血脂水平（包括总胆固醇和非高密度脂蛋白胆固醇）与母体血脂水平呈相关性，相关系数>0.3。然而，经阴道分娩病例的脐带血清中饱和脂肪酸、单不饱和脂肪酸和总脂肪酸水平，以及非高密度脂蛋白、低密度脂蛋白、极低密度脂蛋白、中间密度脂蛋白和游离脂肪酸组分中的水平显著更高（P<0.01）。
经阴道分娩期间，脐带血清中饱和脂肪酸和单不饱和脂肪酸水平升高。
