Albertazzi P, Pansini F, Bottazzi M, Bonaccorsi G, De Aloysio D, Morton M S
Menopause and Osteoporosis Center, University of Ferrara, Italy.
Obstet Gynecol. 1999 Aug;94(2):229-31. doi: 10.1016/s0029-7844(99)00275-6.
To investigate the relationship between levels of phytoestrogens in blood and urine and symptom control in postmenopausal women whose diets were supplemented with soy containing high levels of phytoestrogen.
Phytoestrogen levels in blood and urine were correlated with the number of hot flushes and vaginal maturation indices in 104 postmenopausal women whose diets were supplemented with 60 g of soy powder daily for 3 months in a double-masked, parallel, placebo-controlled trial. The effect of soy supplementation on menopausal symptoms in this study population was reported previously.
Serum levels of genistin, daidzin, and equol were significantly higher in women after soy diet supplementation (+756%, +593%, +1008%, and 57% respectively). The concentration of enterolactone in the soy group was increased by 57% compared with baseline, but the difference with placebo was not statistically significant. The increase in phytoestrogen levels in the soy group in blood or urine did not correlate with fewer hot flushes. Vaginal maturation indices did not change in the soy group.
Phytoestrogen levels increased in women who consumed soy supplement, but that does not fully explain climacteric symptom reduction. It is possible that other types of yet unknown phytoestrogens or components in soy other than phytoestrogen influence hot flushes.
研究饮食中添加高含量植物雌激素大豆的绝经后女性血液和尿液中植物雌激素水平与症状控制之间的关系。
在一项双盲、平行、安慰剂对照试验中，对104名绝经后女性进行研究，她们的饮食中每天添加60克大豆粉，持续3个月，将血液和尿液中的植物雌激素水平与潮热次数和阴道成熟指数进行关联分析。此前已报道过该研究人群中大豆补充剂对更年期症状的影响。
补充大豆饮食后，女性血清中染料木苷、大豆苷和雌马酚水平显著升高（分别升高756%、593%、1008%和57%）。大豆组中肠内酯的浓度较基线增加了57%，但与安慰剂组的差异无统计学意义。大豆组血液或尿液中植物雌激素水平的升高与潮热次数减少无关。大豆组的阴道成熟指数没有变化。
食用大豆补充剂的女性植物雌激素水平升高，但这并不能完全解释更年期症状的减轻。可能是大豆中其他类型尚未知晓的植物雌激素或除植物雌激素外的其他成分影响了潮热。
