Wauquier A, Melis W, Niemegeers C J, Janssen P A
Psychopharmacology (Berl). 1978 Dec 8;59(3):255-8. doi: 10.1007/BF00426630.
The interaction between various doses of apomorphine and haloperidol on intracranial self-stimulation in the dog was studied using a pradigm in which reinforcing brain-stimulation was controlled by a discriminative auditory stimulus. Reinforced lever-pressing was decreased by low doses of apomorphine and completely suppressed by stereotypogenic doses. At various doses of apomorphine, low doses of haloperidol either increased response inhibition by enhancing stereotypy, or increased lever pressing by reducing stereotypy while concomitantly increasing the number of nonreinforced responses. Intermediate to relatively high doses of haloperidol antagonized stereotypy and the response inhibition produced by apomorphine. High doses of haloperidol antagonized stereotypy but also suppressed self-stimulation. Thus, haloperidol is not only able to restore performance capability, but also disturbed reinforcing and discriminative stimulus control.
利用一种范式研究了不同剂量的阿扑吗啡和氟哌啶醇对犬颅内自身刺激的相互作用，在该范式中，强化脑刺激由辨别性听觉刺激控制。低剂量的阿扑吗啡可降低强化的杠杆按压，而成瘾性剂量则可完全抑制。在不同剂量的阿扑吗啡作用下，低剂量的氟哌啶醇要么通过增强刻板行为增加反应抑制，要么通过减少刻板行为同时增加非强化反应的数量来增加杠杆按压。中等至高剂量的氟哌啶醇可拮抗阿扑吗啡产生的刻板行为和反应抑制。高剂量的氟哌啶醇可拮抗刻板行为，但也会抑制自身刺激。因此，氟哌啶醇不仅能够恢复行为能力，还会干扰强化和辨别性刺激控制。
