Goldberg M S, Siemiatyck J, DeWar R, Désy M, Riberdy H
Epidemiology and Biostatistics Unit, Institute Armand-Frappier, University of Quebec, Laval, Canada.
Arch Environ Health. 1999 Jul-Aug;54(4):291-6. doi: 10.1080/00039899909602488.
In this study, we sought to determine whether men who lived near the Miron Quarry municipal solid waste landfill site in Montreal, Quebec, Canada, were at higher risk for developing cancer than individuals who lived at more remote locations. Subjects were selected from a previously completed population-based, interview, cancer case-control study of men who lived in metropolitan Montreal. Thirteen sites of cancer (n = 2 928 subjects) and a population-based control group (n = 417) were analyzed. We used the exact street address at the time of diagnosis to classify subjects by geographic zones and distance from the site. We used unconditional logistic regression to estimate odds ratios (ORs) and associated 95% confidence intervals (CIs) for each site of cancer, adjusted for key covariates. In the exposure zone nearest to the site, elevated risks were found for cancers of the pancreas (adjusted OR = 1.4 [95% CI = 0.8, 2.6]); liver (OR = 1.8 [95% CI = 0.8, 4.3]); and prostate (OR = 1.5 [95% CI = 1.0, 2.1]). A high risk was also found for pancreatic cancer (OR = 1.7 [95% CI = 0.9, 3.5]) and the non-Hodgkin's lymphomas (OR = 1.5 [95% CI = 0.8, 2.6]) in a subexposure zone approximately downwind from the site. We used distance from the site as another exposure metric, and higher-than-expected risks were found for pancreatic cancer (OR for living within 1.25 km of the site [OR<1.25km] = 2.2 [95% CI = 1.0, 4.6]); liver cancer (OR<1.5km = 2.1 [95% CI = 0.8, 5.3]); kidney cancer (OR<2 km = 1.4 [95% CI = 0.9, 2.3]); and the non-Hodgkin's lymphomas (OR<1km = 2.0 [95% CI = 1.0, 4.0]). Data from this study and from a previous investigation at the same site suggest that men who lived near this landfill site may have been-and may continue to be-at excess risk of cancers of the liver, kidney, pancreas, and non-Hodgkin's lymphomas.
在本研究中，我们试图确定居住在加拿大魁北克省蒙特利尔市米隆采石场城市固体废弃物填埋场附近的男性，相较于居住在更偏远地区的人，患癌风险是否更高。研究对象选自此前一项已完成的针对居住在蒙特利尔市的男性的基于人群的访谈式癌症病例对照研究。分析了13种癌症的患者（n = 2928名受试者）以及一个基于人群的对照组（n = 417名）。我们根据诊断时的确切街道地址，按地理区域和与填埋场的距离对受试者进行分类。我们使用无条件逻辑回归来估计每种癌症的比值比（OR）及相关的95%置信区间（CI），并对关键协变量进行了调整。在距离填埋场最近的暴露区，发现胰腺癌（调整后OR = 1.4 [95% CI = 0.8, 2.6]）、肝癌（OR = 1.8 [95% CI = 0.8, 4.3]）和前列腺癌（OR = 1.5 [95% CI = 1.0, 2.1]）的风险升高。在填埋场大致下风方向的一个次暴露区，也发现胰腺癌（OR = 1.7 [95% CI = 0.9, 3.5]）和非霍奇金淋巴瘤（OR = 1.5 [95% CI = 0.8, 2.6]）的风险较高。我们将与填埋场的距离作为另一种暴露指标，发现胰腺癌（居住在距离填埋场1.25公里以内的OR [OR<1.25km] = 2.2 [95% CI = 1.0, 4.6]）、肝癌（OR<1.5km = 2.1 [95% CI = 0.8, 5.3]）、肾癌（OR<2公里 = 1.4 [95% CI = 0.9, 2.3]）和非霍奇金淋巴瘤（OR<1公里 = 2.0 [95% CI = 1.0, 4.0]）的风险高于预期。本研究以及此前在同一地点的调查数据表明，居住在该填埋场附近的男性可能已经——并且可能继续——面临患肝癌、肾癌、胰腺癌和非霍奇金淋巴瘤的额外风险。
